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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f081RSTyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4f081RSTyrosine-protein kinase JAK2/1.000
4aqc88ATyrosine-protein kinase JAK2/0.610
3lpbNVBTyrosine-protein kinase JAK2/0.572
4hge15VTyrosine-protein kinase JAK2/0.569
4ehzJAKTyrosine-protein kinase JAK1/0.568
4e6d0NUTyrosine-protein kinase JAK2/0.563
4i5cC5ITyrosine-protein kinase JAK1/0.560
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.542
4fk60UJTyrosine-protein kinase JAK1/0.534
4bbfO19Tyrosine-protein kinase JAK2/0.522
4hvi19STyrosine-protein kinase JAK32.7.10.20.517
4e4n0NLTyrosine-protein kinase JAK1/0.513
4fv6E57Mitogen-activated protein kinase 12.7.11.240.501
4e6q0NVTyrosine-protein kinase JAK2/0.500
4jia1K3Tyrosine-protein kinase JAK2/0.497
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.495
4ji91M3Tyrosine-protein kinase JAK2/0.492
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.477
3qxpX64Cyclin-dependent kinase 22.7.11.220.474
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.470
1fvv107Cyclin-dependent kinase 22.7.11.220.468
2uzbC75Cyclin-dependent kinase 22.7.11.220.468
4ivb1J5Tyrosine-protein kinase JAK1/0.467
3i60E86Mitogen-activated protein kinase 12.7.11.240.465
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.463
1yvj4STTyrosine-protein kinase JAK32.7.10.20.462
3rak03ZCyclin-dependent kinase 22.7.11.220.462
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.457
2vu3LZECyclin-dependent kinase 22.7.11.220.455
4anmWULCasein kinase II subunit alpha2.7.11.10.455
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.452
3s1h56ZCyclin-dependent kinase 22.7.11.220.451
4eooATPCyclin-dependent kinase 22.7.11.220.447
3w2sW2REpidermal growth factor receptor2.7.10.10.446
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.445
2yaaATPDeath-associated protein kinase 2/0.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.442
3nux3NVCyclin-dependent kinase 62.7.11.220.442
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.442
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.441
2pvhP19Casein kinase II subunit alpha2.7.11.10.441
2xa4AZ5Tyrosine-protein kinase JAK2/0.441
3eb0DRKUncharacterized protein/0.441
4e5w0NTTyrosine-protein kinase JAK1/0.441
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.441