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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ez8DHFThymidylate synthase2.1.1.45

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ez8DHFThymidylate synthase2.1.1.451.000
2ftoCB3Thymidylate synthase/0.550
1tysDHFThymidylate synthase/0.522
3bhrTHGThymidylate synthase/0.521
3bhlTHGThymidylate synthase/0.520
4gevCB3Thymidylate synthase/0.508
4isk1JYThymidylate synthase/0.505
1tduCB3Thymidylate synthase/0.503
3bgxMEFThymidylate synthase/0.497
1an5CB3Thymidylate synthase/0.495
1fwmCB3Thymidylate synthase/0.483
4knzCB3Thymidylate synthase/0.482
1dduCB3Thymidylate synthase/0.480
4einNOHThymidylate synthase2.1.1.450.478
1f4fTP3Thymidylate synthase/0.477
4fogC2FThymidylate synthase ThyA/0.476
4o7uTHFThymidylate synthase/0.470
3bgxTMPThymidylate synthase/0.467
2ftoTMPThymidylate synthase/0.466
2vf0F89Thymidylate synthase/0.466
1tduDURThymidylate synthase/0.465
1tysTMPThymidylate synthase/0.461
1dduDDUThymidylate synthase/0.443
1tlcF89Thymidylate synthase/0.442
1f4gTP4Thymidylate synthase/0.440