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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dscA8SAbscisic acid receptor PYL3

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dscA8SAbscisic acid receptor PYL3/1.000
4dsbA8SAbscisic acid receptor PYL3/0.585
3njoP2MAbscisic acid receptor PYR1/0.560
3njoPYVAbscisic acid receptor PYR1/0.557
3nj0PYVAbscisic acid receptor PYL2/0.553
3nmpPYVAbscisic acid receptor PYL2/0.541
3ns2PYVAbscisic acid receptor PYL2/0.534
4jdaA9SAbscisic acid receptor PYL3/0.514
3nmhPYVAbscisic acid receptor PYL2/0.507
3ujlA8SAbscisic acid receptor PYL2/0.506
3r6pA8SAbscisic acid receptor PYL10/0.505
3oquA8SAbscisic acid receptor PYL9/0.491
1og5SWFCytochrome P450 2C9/0.488
3l70JZVCytochrome b/0.485
1ot7CHCBile acid receptor/0.470
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3kdiA8SAbscisic acid receptor PYL2/0.464
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.464
5k2cZMAAdenosine receptor A2a/0.464
3h1jSMACytochrome b/0.462
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.461
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3gwfFADCyclohexanone monooxygenase/0.460
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4equG6ISerine/threonine-protein kinase 102.7.11.10.459
1osvCHCBile acid receptor/0.458
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2bxoOPBSerum albumin/0.457
3irn1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.457
3zsh469Mitogen-activated protein kinase 14/0.457
3kb0A8SAbscisic acid receptor PYL2/0.456
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
4geb0LDKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.456
5k2aZMAAdenosine receptor A2a/0.456
1fdwESTEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
3vtbTKAVitamin D3 receptor/0.452
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
1s19MC9Vitamin D3 receptor/0.451
3bfb9ODPheromone-binding protein ASP1/0.451
3w9rA8SAbscisic acid receptor PYL9/0.451
4ia1BIVVitamin D3 receptor A/0.451
4jbtASDCytochrome P450 monooxygenase/0.451
1rk3VDXVitamin D3 receptor/0.450
2ydoADNAdenosine receptor A2a/0.450
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
5k2bZMAAdenosine receptor A2a/0.450
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.449
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3l0lHC3Nuclear receptor ROR-gamma/0.449
3qlrNDPDihydrofolate reductase1.5.1.30.449
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.449
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
4uhrNGIAdenosine receptor A2a/0.448
3emlZMAAdenosine receptor A2a/0.448
1l2jETCEstrogen receptor beta/0.447
2imkGTXAGAP009194-PA/0.447
4g1z0VPVitamin D3 receptor A/0.447
4nc3ERM5-hydroxytryptamine receptor 2B/0.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
3kb3A8SAbscisic acid receptor PYL2/0.446
3qly55VUncharacterized protein/0.446
1zgaHMKIsoflavone 4'-O-methyltransferase/0.445
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.445
3anmNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.445
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
4klrCHDFerrochelatase, mitochondrial4.99.1.10.445
4oicA8SBet v I allergen-like/0.445
1sr7MOFProgesterone receptor/0.444
1uqtU2FTrehalose-6-phosphate synthase2.4.1.150.444
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
2ydvNECAdenosine receptor A2a/0.444
2zlcVDXVitamin D3 receptor/0.444
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3uzcT4EAdenosine receptor A2a/0.444
1txiTX5Vitamin D3 receptor/0.443
3ojiPYVAbscisic acid receptor PYL3/0.443
3qlhT27Gag-Pol polyprotein2.7.7.490.443
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4iaq2GM5-hydroxytryptamine receptor 1B/0.443
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
2i0ePDSProtein kinase C beta type2.7.11.130.442
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.442
2yiuSMACytochrome b/0.442
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3vruYS3Vitamin D3 receptor/0.442
3zvuA8SAbscisic acid receptor PYR1/0.442
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3h0sB38Acetyl-CoA carboxylase/0.441
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.441
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.441
3vt9YI4Vitamin D3 receptor/0.441
5k2dZMAAdenosine receptor A2a/0.441
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
2ociTYCValacyclovir hydrolase3.10.440
3cseN22Uncharacterized protein/0.440
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3vrvYSDVitamin D3 receptor/0.440
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4j6cSTRCytochrome P450 monooxygenase/0.440
4r20AERCytochrome P450 family 17 polypeptide 2/0.440
5jtbZMAAdenosine receptor A2a/0.440