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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dgnLU2Casein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4dgnLU2Casein kinase II subunit alpha2.7.11.11.000
3be9P04Casein kinase II subunit alpha2.7.11.10.618
1m2pHNACasein kinase II subunit alpha2.7.11.10.607
2pvlP55Casein kinase II subunit alpha2.7.11.10.582
4anmWULCasein kinase II subunit alpha2.7.11.10.575
1om1IQACasein kinase II subunit alpha2.7.11.10.571
4dgmAGICasein kinase II subunit alpha2.7.11.10.557
2pvnP63Casein kinase II subunit alpha2.7.11.10.539
2pvhP19Casein kinase II subunit alpha2.7.11.10.534
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.527
3q9xEMOCasein kinase II subunit alpha2.7.11.10.520
4dgo0JWCasein kinase II subunit alpha2.7.11.10.506
4grb0XGCasein kinase II subunit alpha2.7.11.10.498
1dayGNPCasein kinase II subunit alpha2.7.11.10.492
1dawANPCasein kinase II subunit alpha2.7.11.10.489
2pvmP29Casein kinase II subunit alpha2.7.11.10.489
1m2rMNYCasein kinase II subunit alpha2.7.11.10.475
2pvjP44Casein kinase II subunit alpha2.7.11.10.468
3axwTIDCasein kinase II subunit alpha2.7.11.10.467
5cvfATPCasein kinase II subunit alpha2.7.11.10.463
3at4CCKCasein kinase II subunit alpha2.7.11.10.461
1lp4ANPCasein kinase II subunit alpha2.7.11.10.457
4hge15VTyrosine-protein kinase JAK2/0.452
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.451
4hvi19STyrosine-protein kinase JAK32.7.10.20.451
2w05FRTCyclin-dependent kinase 22.7.11.220.443
4aqc88ATyrosine-protein kinase JAK2/0.443