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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c4iX20Dual specificity protein kinase TTK2.7.12.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4c4iX20Dual specificity protein kinase TTK2.7.12.11.000
4c4f7CEDual specificity protein kinase TTK2.7.12.10.633
4c4h7RODual specificity protein kinase TTK2.7.12.10.627
4c4g7RODual specificity protein kinase TTK2.7.12.10.622
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.599
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.585
5ap57RODual specificity protein kinase TTK2.7.12.10.561
2zmd537Dual specificity protein kinase TTK2.7.12.10.523
5ap7SVEDual specificity protein kinase TTK2.7.12.10.508
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.490
4b99R4LMitogen-activated protein kinase 72.7.11.240.446
4id71G0Activated CDC42 kinase 1/0.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.445