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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bznUGXSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bznUGXSerine/threonine-protein kinase pim-12.7.11.11.000
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.739
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.565
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.553
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.547
4bgg844Activin receptor type-12.7.11.300.536
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.531
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.528
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.527
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.526
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.524
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.515
3mtfA3FActivin receptor type-12.7.11.300.515
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.515
4dymIYZActivin receptor type-12.7.11.300.515
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.511
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.507
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.505
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.504
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.501
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.501
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.496
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.493
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.490
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.483
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.481
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.479
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.478
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.477
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.476
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.476
4c02TAKActivin receptor type-12.7.11.300.473
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.472
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.470
4anmWULCasein kinase II subunit alpha2.7.11.10.470
3umw596Serine/threonine-protein kinase pim-12.7.11.10.468
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.465
3hmm855TGF-beta receptor type-12.7.11.300.463
3be9P04Casein kinase II subunit alpha2.7.11.10.461
2cdaNAPGlucose 1-dehydrogenase/0.459
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.458
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.458
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.458
1om1IQACasein kinase II subunit alpha2.7.11.10.457
4hge15VTyrosine-protein kinase JAK2/0.456
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.456
2pvlP55Casein kinase II subunit alpha2.7.11.10.454
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.452
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.452
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.452
4ux9ANPMitogen-activated protein kinase 82.7.11.240.452
2pvhP19Casein kinase II subunit alpha2.7.11.10.451
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.451
3q9xEMOCasein kinase II subunit alpha2.7.11.10.451
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.451
2xizXIZSerine/threonine-protein kinase pim-12.7.11.10.450
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.450
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.450
4tuvCPZCytochrome P450 1191.140.449
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.448
3pe2E1BCasein kinase II subunit alpha2.7.11.10.448
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
1dawANPCasein kinase II subunit alpha2.7.11.10.446
4dgnLU2Casein kinase II subunit alpha2.7.11.10.446
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.445
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.444
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.444
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.444
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
1vjy460TGF-beta receptor type-12.7.11.300.442
1m2pHNACasein kinase II subunit alpha2.7.11.10.440
3hx4ANPCalmodulin-domain protein kinase 1/0.440
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.440