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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.25

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.251.000
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.509
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.500
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.491
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.468
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.468
4jboWPHAurora kinase A2.7.11.10.466
2w05FRTCyclin-dependent kinase 22.7.11.220.460
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.456
2vu3LZECyclin-dependent kinase 22.7.11.220.455
1yvj4STTyrosine-protein kinase JAK32.7.10.20.453
4jbqVX6Aurora kinase A2.7.11.10.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
3w2rW2REpidermal growth factor receptor2.7.10.10.451
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.449
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.449
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.449
4y93746Tyrosine-protein kinase/0.448
4o0wADNAurora kinase A2.7.11.10.447
3l8p0CEAngiopoietin-1 receptor2.7.10.10.446
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.446
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.445
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.445
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.444
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
4erwSTUCyclin-dependent kinase 22.7.11.220.443
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
3qxpX64Cyclin-dependent kinase 22.7.11.220.442
3ttjJBIMitogen-activated protein kinase 102.7.11.240.442
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
3t2zFADSulfide-quinone reductase/0.441
3sz0FADSulfide-quinone reductase/0.440