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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w3oROEDihydroorotate dehydrogenase (fumarate)1.3.98.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3w3oROEDihydroorotate dehydrogenase (fumarate)1.3.98.11.000
3w2jQRODihydroorotate dehydrogenase (fumarate)1.3.98.10.587
3w1xXRODihydroorotate dehydrogenase (fumarate)1.3.98.10.544
3w2mZRODihydroorotate dehydrogenase (fumarate)1.3.98.10.528
3w1tWRODihydroorotate dehydrogenase (fumarate)1.3.98.10.524
3w2uROUDihydroorotate dehydrogenase (fumarate)1.3.98.10.513
3w1qYRODihydroorotate dehydrogenase (fumarate)1.3.98.10.508
3w233RODihydroorotate dehydrogenase (fumarate)1.3.98.10.500
3w2nRODDihydroorotate dehydrogenase (fumarate)1.3.98.10.491
1udaUFGUDP-glucose 4-epimerase5.1.3.20.490
3w1rMRODihydroorotate dehydrogenase (fumarate)1.3.98.10.487
1xelUPGUDP-glucose 4-epimerase5.1.3.20.474
1udbUFGUDP-glucose 4-epimerase5.1.3.20.470
2y0mACOHistone acetyltransferase KAT8/0.470
3d3wNAPL-xylulose reductase1.1.1.100.463
3otwCOAPhosphopantetheine adenylyltransferase/0.456
4h3j10WBeta-secretase 13.4.23.460.454
2ou2ACOHistone acetyltransferase KAT5/0.453
3drcMTXDihydrofolate reductase1.5.1.30.453
2givACOHistone acetyltransferase KAT8/0.451
4frkDWDBeta-secretase 13.4.23.460.451
1udcUFMUDP-glucose 4-epimerase5.1.3.20.450
2c20NADUDP-glucose 4-epimerase/0.450
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.449
1mj9COAHistone acetyltransferase ESA1/0.449
3ieuGDPGTPase Era/0.449
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.449
1f8fNADBenzyl alcohol dehydrogenase/0.448
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.448
1xe55FEPlasmepsin-23.4.23.390.447
2gjlFMNNitronate monooxygenase1.13.12.160.446
4eywL0RCarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.446
1mjbACOHistone acetyltransferase ESA1/0.445
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.445
1a9yUPGUDP-glucose 4-epimerase5.1.3.20.444
1h50FMNPentaerythritol tetranitrate reductase/0.444
2g8yNADHydroxycarboxylate dehydrogenase B/0.444
5bsfNADPyrroline-5-carboxylate reductase/0.444
1wntNAPL-xylulose reductase1.1.1.100.442
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
4q71FADBifunctional protein PutA/0.442
2ejvNADL-threonine 3-dehydrogenase/0.441
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.441
3w2lVRODihydroorotate dehydrogenase (fumarate)1.3.98.10.441