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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.15

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3v5w8PRBeta-adrenergic receptor kinase 12.7.11.151.000
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.613
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.511
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.489
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
5av2KMPDeath-associated protein kinase 12.7.11.10.484
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
2yaaATPDeath-associated protein kinase 2/0.480
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.472
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
5aut2ANDeath-associated protein kinase 12.7.11.10.470
2f2uM77Rho-associated protein kinase 22.7.11.10.468
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3juhANPCasein kinase II subunit alpha2.7.11.10.464
5av3KMPDeath-associated protein kinase 12.7.11.10.464
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.459
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.456
4e4n0NLTyrosine-protein kinase JAK1/0.456
1jklANPDeath-associated protein kinase 12.7.11.10.454
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.452
3ncz3NCRho-associated protein kinase 12.7.11.10.452
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
5dt0SKEAurora kinase A2.7.11.10.449
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.448
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.445
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.445
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3gu83GUDeath-associated protein kinase 12.7.11.10.444
3oogYTPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4otiMI1Serine/threonine-protein kinase N1/0.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.441
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440