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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ugc046Tyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ugc046Tyrosine-protein kinase JAK2/1.000
3nnuEDBMitogen-activated protein kinase 14/0.544
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.544
3p5kP5KMitogen-activated protein kinase 14/0.539
3p7bP7BMitogen-activated protein kinase 14/0.523
3hv6R39Mitogen-activated protein kinase 14/0.522
1wbtWBTMitogen-activated protein kinase 14/0.520
3gi3B10Mitogen-activated protein kinase 14/0.519
3hv71AUMitogen-activated protein kinase 14/0.516
2e2b406Tyrosine-protein kinase ABL12.7.10.20.514
3nnxEDDMitogen-activated protein kinase 14/0.513
3uvr06FMitogen-activated protein kinase 14/0.513
3p79P79Mitogen-activated protein kinase 14/0.509
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.508
1wbnL09Mitogen-activated protein kinase 14/0.500
1w82L10Mitogen-activated protein kinase 14/0.499
3kq7KQ7Mitogen-activated protein kinase 14/0.499
1wbsLI2Mitogen-activated protein kinase 14/0.495
3k3jF4CMitogen-activated protein kinase 14/0.494
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.10.493
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.491
2hznKINTyrosine-protein kinase ABL12.7.10.20.490
3gcuR48Mitogen-activated protein kinase 14/0.490
2hz0GINTyrosine-protein kinase ABL12.7.10.20.488
2hiw7MPTyrosine-protein kinase ABL12.7.10.20.487
3e9319BMitogen-activated protein kinase 14/0.486
2puuG2GMitogen-activated protein kinase 14/0.485
1wbvLI3Mitogen-activated protein kinase 14/0.484
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.481
4aa0AA0Mitogen-activated protein kinase 14/0.476
1kv2B96Mitogen-activated protein kinase 14/0.475
3orn3ORDual specificity mitogen-activated protein kinase kinase 12.7.12.20.475
3p7cP7CMitogen-activated protein kinase 14/0.475
3gvuSTIAbelson tyrosine-protein kinase 22.7.10.20.474
3p7aP7AMitogen-activated protein kinase 14/0.474
4hw764MMacrophage colony-stimulating factor 1 receptor2.7.10.10.472
4eh90OQMitogen-activated protein kinase 14/0.470
4kigENOPhenylpyruvate C(3)-methyltransferase2.1.1.2810.467
3nnwEDDMitogen-activated protein kinase 14/0.466
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.463
3gcvSS6Mitogen-activated protein kinase 14/0.462
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.462
3vvh4BMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.460
3p78P78Mitogen-activated protein kinase 14/0.459
1j39UPGDNA beta-glucosyltransferase/0.457
4h4xFADBiphenyl dioxygenase ferredoxin reductase subunit/0.457
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
2vwpNDPGlucose 1-dehydrogenase/0.451
4ei7GDPPlasmid replication protein RepX/0.450
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.447
2yisYISMitogen-activated protein kinase 14/0.447
2p55MRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
5dhhDGWNociceptin receptor/0.446
2uxuNARHTH-type transcriptional regulator TtgR/0.444
4c2uANPDNA helicase/0.444
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.444
3v04V04Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4l8mF46Mitogen-activated protein kinase 14/0.443
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.442
3v013V0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
1rdwLARActin, alpha skeletal muscle/0.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.441
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.440
2yy8MTAtRNA (cytidine(56)-2'-O)-methyltransferase/0.440
3aidARQGag-Pol polyprotein3.4.23.160.440
3qakUKAAdenosine receptor A2a/0.440