scPDB - Distribution of Cavity Similarity values of 3qlz entry / Site 1

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3qlz	QLZ	Uncharacterized protein

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
3qlz	QLZ	Uncharacterized protein	/	1.000
3eek	53S	Uncharacterized protein	/	0.770
3cse	N22	Uncharacterized protein	/	0.720
3eel	53T	Uncharacterized protein	/	0.709
4h98	14Q	Uncharacterized protein	/	0.680
3eej	53R	Uncharacterized protein	/	0.666
3qly	55V	Uncharacterized protein	/	0.653
3eem	53V	Uncharacterized protein	/	0.616
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.592
3qlx	QLR	Uncharacterized protein	/	0.589
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.579
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.578
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.574
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.573
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.572
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.567
1m78	CLZ	Dihydrofolate reductase	1.5.1.3	0.567
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.559
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.558
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.557
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.553
2bl9	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.551
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.549
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.548
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.545
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.543
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.539
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.537
2w3v	TOP	Dihydrofolate reductase	/	0.536
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.536
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.534
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.533
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.528
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.526
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.524
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.515
1ia1	TQ3	Dihydrofolate reductase	1.5.1.3	0.514
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.514
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.512
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.510
3ia4	MTX	Dihydrofolate reductase	/	0.510
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.510
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.510
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.510
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.509
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.509
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.508
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.508
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.506
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.504
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.504
2blb	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.502
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.500
1ia2	TQ4	Dihydrofolate reductase	1.5.1.3	0.499
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.497
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.496
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.494
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.493
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.493
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.492
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.491
3sa1	6DR	Dihydrofolate reductase	/	0.491
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.490
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.489
3jwm	5WB	Dihydrofolate reductase	/	0.489
3sa2	7DR	Dihydrofolate reductase	/	0.489
3dg8	RJ6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.488
3jwc	EKB	Dihydrofolate reductase	/	0.487
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.486
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.485
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.483
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.483
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.481
4ele	31I	Dihydrofolate reductase	/	0.481
4kbn	25U	Dihydrofolate reductase	1.5.1.3	0.481
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.480
2cig	1DG	Dihydrofolate reductase	1.5.1.3	0.480
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.480
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.476
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.476
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.474
3kjs	NAP	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.474
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.473
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.472
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.470
4p66	MTX	Dihydrofolate reductase	/	0.469
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.467
4nky	3QZ	Steroid 17-alpha-hydroxylase/17,20 lyase	/	0.466
2zza	FOL	Dihydrofolate reductase	/	0.465
1ia4	TQ6	Dihydrofolate reductase	1.5.1.3	0.464
3inv	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
3jw5	TOP	Dihydrofolate reductase	/	0.463
3r33	6ME	Dihydrofolate reductase	1.5.1.3	0.463
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.463
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.462
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.462
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.460
1og5	SWF	Cytochrome P450 2C9	/	0.459
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.457
3sai	9DR	Dihydrofolate reductase	/	0.457
3qls	NDP	Dihydrofolate reductase	1.5.1.3	0.456
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.455
3tq9	MTX	Dihydrofolate reductase	/	0.455
1m79	MQ1	Dihydrofolate reductase	1.5.1.3	0.453
3nxv	D2F	Dihydrofolate reductase	1.5.1.3	0.453
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.453
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.453
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.452
2w3w	VG9	Dihydrofolate reductase	/	0.451
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.451
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.450
3tqb	FOL	Dihydrofolate reductase	/	0.450
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.448
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.448
3dg8	NDP	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.446
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.444
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.443
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.442
4elg	52J	Dihydrofolate reductase	/	0.442
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.442
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.441
1s3w	TQT	Dihydrofolate reductase	1.5.1.3	0.440
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.440