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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pheC9ARNA-directed RNA polymerase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3pheC9ARNA-directed RNA polymerase/1.000
1nhv154Genome polyprotein2.7.7.480.500
2girNN3Genome polyprotein2.7.7.480.489
4jty1NVGenome polyprotein2.7.7.480.466
4ku2MYA3-oxoacyl-[ACP] synthase III/0.459
4gncASORegucalcin3.1.1.170.452
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.451
4ejgNCTCytochrome P450 2A131.14.14.10.450
4em3FADCoenzyme A disulfide reductase/0.448
3nl6TPSUncharacterized protein/0.447
4ivgANPTNF receptor-associated protein 1/0.446
1eiiRTLRetinol-binding protein 2/0.445
4lb2DM5Serum albumin/0.445
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.445
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.444
1g1aNADdTDP-glucose 4,6-dehydratase/0.443
1tu3GNPRas-related protein Rab-5A/0.443
4xgxADPFAD:protein FMN transferase/0.443
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.442
5esoTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.442
3ogqAB1Pol polyprotein/0.441