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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mb9ZSTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3mb9ZSTAldose reductase1.1.1.211.000
2hv5ZSTAldose reductase1.1.1.210.640
2fz8ZSTAldose reductase1.1.1.210.635
2fz9ZSTAldose reductase1.1.1.210.630
3lenZSTAldose reductase1.1.1.210.630
2dv0ZSTAldose reductase1.1.1.210.620
3m0iZSTAldose reductase1.1.1.210.607
1z3n3NAAldose reductase1.1.1.210.603
2pdxZSTAldose reductase1.1.1.210.601
1ieiZESAldose reductase1.1.1.210.600
1pwlBFIAldose reductase1.1.1.210.599
2pdg47DAldose reductase1.1.1.210.594
3m4h388Aldose reductase1.1.1.210.585
1z8962PAldose reductase1.1.1.210.584
3lboLDTAldose reductase1.1.1.210.584
3lqlLDTAldose reductase1.1.1.210.583
2pdn47DAldose reductase1.1.1.210.582
2pd5ZSTAldose reductase1.1.1.210.581
3mc5393Aldose reductase1.1.1.210.580
2i16LDTAldose reductase1.1.1.210.579
1t40ID5Aldose reductase1.1.1.210.577
2hvoZSTAldose reductase1.1.1.210.576
2pdbZSTAldose reductase1.1.1.210.572
2duxZSTAldose reductase1.1.1.210.567
4gca2X9Aldose reductase1.1.1.210.565
2pdh47DAldose reductase1.1.1.210.564
2pdc393Aldose reductase1.1.1.210.561
2pdp393Aldose reductase1.1.1.210.561
2ikj393Aldose reductase1.1.1.210.560
3ghsLDTAldose reductase1.1.1.210.560
3ghtLDTAldose reductase1.1.1.210.560
4yu153NAldose reductase1.1.1.210.560
3ghuLDTAldose reductase1.1.1.210.556
3m64393Aldose reductase1.1.1.210.555
2iki388Aldose reductase1.1.1.210.554
3ghrLDTAldose reductase1.1.1.210.554
1frbZSTAldose reductase-related protein 2/0.552
3ld5LDTAldose reductase1.1.1.210.551
2i17LDTAldose reductase1.1.1.210.550
3g5eQ74Aldose reductase1.1.1.210.548
2pzn393Aldose reductase1.1.1.210.546
2qxwLDTAldose reductase1.1.1.210.546
1us0LDTAldose reductase1.1.1.210.544
1t41ID5Aldose reductase1.1.1.210.537
3t423T4Aldose reductase1.1.1.210.530
2duzZSTAldose reductase1.1.1.210.528
3lz5LDTAldose reductase1.1.1.210.525
2pdu393Aldose reductase1.1.1.210.521
2fzdTOLAldose reductase1.1.1.210.507
2pdlTOLAldose reductase1.1.1.210.495
2ikhLITAldose reductase1.1.1.210.490
2pdfZSTAldose reductase1.1.1.210.490
2iqdLPAAldose reductase1.1.1.210.482
1ah3TOLAldose reductase1.1.1.210.471
2inzOHPAldose reductase1.1.1.210.470
2pdq47DAldose reductase1.1.1.210.465
2xupTZ5Acetylcholinesterase3.1.1.70.460
2pdyFIDAldose reductase1.1.1.210.457
2xuhTZ4Acetylcholinesterase3.1.1.70.451
2nvcITAAldose reductase1.1.1.210.450
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.450
3af0GDPPantothenate kinase2.7.1.330.449
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.448
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.448
4ga8SBIAldo-keto reductase family 1 member B101.1.10.448
2xuiTZ5Acetylcholinesterase3.1.1.70.447
4ey7E20Acetylcholinesterase3.1.1.70.447
3hl0NADMaleylacetate reductase/0.445
2aotSAHHistamine N-methyltransferase2.1.1.80.444
2xufTZ4Acetylcholinesterase3.1.1.70.444
2v0mKLNCytochrome P450 3A4/0.443
1jqdSAHHistamine N-methyltransferase2.1.1.80.442
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.442
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.441
2qimZEAClass 10 plant pathogenesis-related protein/0.440
2xuoTZ4Acetylcholinesterase3.1.1.70.440
3r43ID8Aldo-keto reductase family 1 member C3/0.440
4e2yJHZMethyltransferase/0.440
4pnmNU1Tankyrase-22.4.2.300.440