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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.11.000
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.537
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.535
4jia1K3Tyrosine-protein kinase JAK2/0.494
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.489
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.486
3js2VM1Fibroblast growth factor receptor 1/0.484
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.467
3zewSTUEphrin type-B receptor 42.7.10.10.466
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.464
4hvi19STyrosine-protein kinase JAK32.7.10.20.462
3uvqFS8Mitogen-activated protein kinase 14/0.460
4bcmT7ZCyclin-dependent kinase 22.7.11.220.460
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3lpbNVBTyrosine-protein kinase JAK2/0.458
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.456
4j98ACPFibroblast growth factor receptor 2/0.456
3w2sW2REpidermal growth factor receptor2.7.10.10.454
4c58824Cyclin-G-associated kinase2.7.11.10.454
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.453
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.453
4bbfO19Tyrosine-protein kinase JAK2/0.453
1yvj4STTyrosine-protein kinase JAK32.7.10.20.452
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4btkDTQTau-tubulin kinase 12.7.11.10.451
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.451
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.450
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.447
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.446
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2ckeIQUDeath-associated protein kinase 2/0.444
3vs1VSATyrosine-protein kinase HCK2.7.10.20.443
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.442
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.441
4j99ACPFibroblast growth factor receptor 2/0.441
3bqr4RBDeath-associated protein kinase 3/0.440
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440