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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.648
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.633
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.564
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.553
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.548
2uvyGVIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.523
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.508
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.497
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2uvzGVJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.461
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.461
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.460
2ed3SAHDiphthine synthase/0.459
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
2ejzSAHDiphthine synthase/0.458
4dymIYZActivin receptor type-12.7.11.300.458
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.458
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.456
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
2lfoGCHFatty acid-binding protein, liver/0.454
1py5PY1TGF-beta receptor type-12.7.11.300.451
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.450
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.450
2ojg19AMitogen-activated protein kinase 12.7.11.240.449
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.448
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.447
3tkuM77Serine/threonine-protein kinase MRCK beta2.7.11.10.446
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1bwlFMNNADPH dehydrogenase 11.6.99.10.445
1xg5NAPDehydrogenase/reductase SDR family member 11/0.445
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1bygSTUTyrosine-protein kinase CSK/0.443
2gjlFMNNitronate monooxygenase1.13.12.160.443
2y99NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.443
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.442
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
1wsvTHHAminomethyltransferase, mitochondrial/0.441
2po7CHDFerrochelatase, mitochondrial4.99.1.10.441
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.441
4e5yNDPGDP-L-fucose synthase1.1.1.2710.441
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.441
3sheI85MAP kinase-activated protein kinase 32.7.11.10.440