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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.611
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.610
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.608
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.592
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.578
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.564
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.545
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.545
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.535
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.530
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.517
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.509
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.473
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.466
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
4hptANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3ntdCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.458
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.455
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2vqdAP2Biotin carboxylase6.3.4.140.453
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4ii5ADPCyclin-dependent kinase 22.7.11.220.451
1qmzATPCyclin-dependent kinase 22.7.11.220.450
5iqhGNPBifunctional AAC/APH2.3.10.450
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3o3pGDDGlycosyl transferase, family 2/0.448
1esvLARActin, alpha skeletal muscle/0.446
3cwkREACellular retinoic acid-binding protein 2/0.446
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
5bylGCPBifunctional AAC/APH2.3.10.446
3av7KYAUncharacterized protein/0.445
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.445
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1jnkANPMitogen-activated protein kinase 102.7.11.240.443
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.443
2cciATPCyclin-dependent kinase 22.7.11.220.443
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
5iqeGNPBifunctional AAC/APH2.3.10.442
2qcsANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4h6rFDAProline dehydrogenase/0.441
4mb2ATPUncharacterized protein/0.441
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440