sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3huc | G97 | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3zsg | T75 | Mitogen-activated protein kinase 14 | / | 0.556 | |
| 3gcp | SB2 | Mitogen-activated protein kinase 14 | / | 0.509 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.489 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.480 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 3zs5 | SB2 | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 1ouk | 084 | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.463 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.455 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.454 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.452 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 3u9e | COA | Lmo1369 protein | / | 0.451 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.450 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.447 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.447 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4cx3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.446 | |
| 1bl7 | SB4 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.445 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.444 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.443 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.442 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.441 |