sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3f82 | 353 | Hepatocyte growth factor receptor | 2.7.10.1 | 1.000 | |
| 3cth | 319 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.592 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.550 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.507 | |
| 3ce3 | 1FN | Hepatocyte growth factor receptor | 2.7.10.1 | 0.507 | |
| 4uxq | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.486 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.478 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.476 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.474 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.474 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.473 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.472 | |
| 4tyj | 0LI | Fibroblast growth factor receptor 4 | 2.7.10.1 | 0.471 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.469 | |
| 3lfb | Z87 | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.463 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.462 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 3nta | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.457 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.455 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.455 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4hni | 16W | Casein kinase I isoform epsilon | 2.7.11.1 | 0.455 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.453 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.452 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.451 | |
| 3c1x | CKK | Hepatocyte growth factor receptor | 2.7.10.1 | 0.450 | |
| 3cse | N22 | Uncharacterized protein | / | 0.449 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 3aba | FLI | Cytochrome P450 | / | 0.447 | |
| 3ntd | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.447 | |
| 4eqx | FAD | Coenzyme A disulfide reductase | / | 0.447 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.445 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4v01 | 0LI | Fibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b | / | 0.445 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.444 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.444 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.444 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2uxi | G50 | HTH-type transcriptional regulator TtgR | / | 0.442 | |
| 3htj | ET | EbrA repressor | / | 0.442 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 3irx | UDR | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.441 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.440 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3jt4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 |