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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.9

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.91.000
2jk6FADTrypanothione reductase/0.563
2wbaFADTrypanothione reductase1.8.1.120.553
4j56FADThioredoxin reductase 21.8.1.90.542
4dnaFADProbable glutathione reductase/0.538
1fecFADTrypanothione reductase1.8.1.120.532
1tytFADTrypanothione reductase1.8.1.120.529
2hqmFADGlutathione reductase1.8.1.70.525
4la1FADThioredoxin glutathione reductase/0.524
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.517
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.515
1gxfFADTrypanothione reductase1.8.1.120.500
2v6oFADThioredoxin glutathione reductase/0.490
4j57FADThioredoxin reductase 21.8.1.90.486
1grhFADGlutathione reductase, mitochondrial1.8.1.70.484
1bzlFADTrypanothione reductase1.8.1.120.474
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.469
1febFADTrypanothione reductase1.8.1.120.467
4nevFADTrypanothione reductase/0.463
1gerFADGlutathione reductase1.8.1.70.462
3grsFADGlutathione reductase, mitochondrial1.8.1.70.452
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.449
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.448