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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xrlDXTTetracycline repressor protein class D

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2xrlDXTTetracycline repressor protein class D/1.000
2o7oDXTTetracycline repressor protein class D/0.672
4d7mTDCTetracycline repressor protein class D/0.661
5fkmTDCTetracycline repressor protein class D/0.655
2tctCTCTetracycline repressor protein class D/0.641
2xpvMIYTetracycline repressor protein class D/0.635
4b3aTACTetracycline repressor protein class D/0.635
2trtTACTetracycline repressor protein class D/0.603
1orkATCTetracycline repressor protein class D/0.598
2xpwOTCTetracycline repressor protein class D/0.593
2fj1CTCTetracycline repressor protein class D/0.591
4auxXTCTetracycline repressor protein class D/0.591
2vkeTACTetracycline repressor protein class D/0.584
2xb5I7TTetracycline repressor protein class D/0.552
2xpuTDCTetracycline repressor protein class D/0.552
4v2gITCTetracycline repressor protein class D/0.545
4abzT1CTetracycline repressor protein class D/0.544
5fklTDCTetracycline repressor protein class D/0.542
2vprTDCTetracycline repressor protein class H/0.519
4b1rITCTetracycline repressor protein class D/0.519
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.508
5fknTDCTetracycline repressor protein class D/0.503
2vkvTDCTetracycline repressor protein class D/0.495
2x9dITCTetracycline repressor protein class D/0.492
2x6o2TCTetracycline repressor protein class D/0.474
2ignFADPyranose 2-oxidase/0.460
5fkoTDCTetracycline repressor protein class D/0.450
1jipKTN6-deoxyerythronolide B hydroxylase/0.449
4gh5NADShort-chain dehydrogenase/reductase SDR/0.449
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.441