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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wxvWXVCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2wxvWXVCyclin-dependent kinase 22.7.11.221.000
2wihP48Cyclin-dependent kinase 22.7.11.220.635
2wpa889Cyclin-dependent kinase 22.7.11.220.544
4fx360KCyclin-dependent kinase 22.7.11.220.525
3bhtMFRCyclin-dependent kinase 22.7.11.220.498
1vyw292Cyclin-dependent kinase 22.7.11.220.496
2wipP49Cyclin-dependent kinase 22.7.11.220.490
1gih1PUCyclin-dependent kinase 22.7.11.220.484
2bkzSBCCyclin-dependent kinase 22.7.11.220.484
3qqkX02Cyclin-dependent kinase 22.7.11.220.484
3s2pPMUCyclin-dependent kinase 22.7.11.220.482
3qu0X40Cyclin-dependent kinase 22.7.11.220.480
3ral04ZCyclin-dependent kinase 22.7.11.220.478
3rmf20ZCyclin-dependent kinase 22.7.11.220.477
2x1nX1NCyclin-dependent kinase 22.7.11.220.476
2bhhRYUCyclin-dependent kinase 22.7.11.220.472
1oguST8Cyclin-dependent kinase 22.7.11.220.471
2iw84SPCyclin-dependent kinase 22.7.11.220.471
1unlRRCCyclin-dependent-like kinase 52.7.11.10.470
1p2a5BNCyclin-dependent kinase 22.7.11.220.469
2cchATPCyclin-dependent kinase 22.7.11.220.467
2w06FRVCyclin-dependent kinase 22.7.11.220.467
3rni21ZCyclin-dependent kinase 22.7.11.220.467
4fkr45KCyclin-dependent kinase 22.7.11.220.467
2i40BLZCyclin-dependent kinase 22.7.11.220.466
4fkw62KCyclin-dependent kinase 22.7.11.220.466
4bcnT9NCyclin-dependent kinase 22.7.11.220.465
4fkv61KCyclin-dependent kinase 22.7.11.220.465
3r9hZ67Cyclin-dependent kinase 22.7.11.220.464
2c6tDT5Cyclin-dependent kinase 22.7.11.220.463
3raiX85Cyclin-dependent kinase 22.7.11.220.463
3rjc06ZCyclin-dependent kinase 22.7.11.220.463
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
3sqq99ZCyclin-dependent kinase 22.7.11.220.462
4qmySTUSerine/threonine-protein kinase 242.7.11.10.462
1fvv107Cyclin-dependent kinase 22.7.11.220.461
3qqfX07Cyclin-dependent kinase 22.7.11.220.460
3rak03ZCyclin-dependent kinase 22.7.11.220.460
3roy22ZCyclin-dependent kinase 22.7.11.220.460
3qtqX35Cyclin-dependent kinase 22.7.11.220.459
1h1r6CPCyclin-dependent kinase 22.7.11.220.458
3tnwF18Cyclin-dependent kinase 22.7.11.220.456
1h1s4SPCyclin-dependent kinase 22.7.11.220.455
1pkdUCNCyclin-dependent kinase 22.7.11.220.455
3qxoX65Cyclin-dependent kinase 22.7.11.220.454
3s1h56ZCyclin-dependent kinase 22.7.11.220.454
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.454
2c5nCK8Cyclin-dependent kinase 22.7.11.220.452
3rpv26ZCyclin-dependent kinase 22.7.11.220.452
1w0xOLOCyclin-dependent kinase 22.7.11.220.451
3pj8404Cyclin-dependent kinase 22.7.11.220.451
3rk507ZCyclin-dependent kinase 22.7.11.220.451
4eos1ROCyclin-dependent kinase 22.7.11.220.451
4fkt48KCyclin-dependent kinase 22.7.11.220.451
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
4bcpT3CCyclin-dependent kinase 22.7.11.220.450
1e9hINRCyclin-dependent kinase 22.7.11.220.449
4bgh3I6Cyclin-dependent kinase 22.7.11.220.449
2c6iDT1Cyclin-dependent kinase 22.7.11.220.448
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.448
3r9dX6BCyclin-dependent kinase 22.7.11.220.448
3rk708ZCyclin-dependent kinase 22.7.11.220.448
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.448
4ek610KCyclin-dependent kinase 22.7.11.220.448
4qmpDKISerine/threonine-protein kinase 242.7.11.10.448
1dm2HMDCyclin-dependent kinase 22.7.11.220.446
1pxmCK5Cyclin-dependent kinase 22.7.11.220.446
3dogNNNCyclin-dependent kinase 22.7.11.220.446
4acm7YGCyclin-dependent kinase 22.7.11.220.446
2uzlC94Cyclin-dependent kinase 22.7.11.220.445
2xnbY8LCyclin-dependent kinase 22.7.11.220.445
3qtzX42Cyclin-dependent kinase 22.7.11.220.445
2btrU73Cyclin-dependent kinase 22.7.11.220.444
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.444
4nj32KDCyclin-dependent kinase 22.7.11.220.444
1oiyN41Cyclin-dependent kinase 22.7.11.220.443
1ke9LS5Cyclin-dependent kinase 22.7.11.220.442
1oirHDYCyclin-dependent kinase 22.7.11.220.442
1v1k3FPCyclin-dependent kinase 22.7.11.220.442
3c4xATPRhodopsin kinase/0.442
3qtxX43Cyclin-dependent kinase 22.7.11.220.442
2btsU32Cyclin-dependent kinase 22.7.11.220.441
2uzdC85Cyclin-dependent kinase 22.7.11.220.441
3a7hATPSerine/threonine-protein kinase 242.7.11.10.440
3r73X87Cyclin-dependent kinase 22.7.11.220.440
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.440