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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vcj2EQHeat shock protein HSP 90-alpha

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vcj2EQHeat shock protein HSP 90-alpha/1.000
2yecXQ0Heat shock protein HSP 90-alpha/0.700
2yi66QMHeat shock protein HSP 90-alpha/0.677
2wi5ZZ5Heat shock protein HSP 90-alpha/0.647
2bsmBSMHeat shock protein HSP 90-alpha/0.626
2vci2GJHeat shock protein HSP 90-alpha/0.626
2wi1ZZ2Heat shock protein HSP 90-alpha/0.622
4fcq2N6Heat shock protein HSP 90-alpha/0.613
2ye92D4Heat shock protein HSP 90-alpha/0.578
4egh0OYHeat shock protein HSP 90-alpha/0.575
2cct2E1Heat shock protein HSP 90-alpha/0.563
2uwd2GGHeat shock protein HSP 90-alpha/0.563
4eftEFTHeat shock protein HSP 90-alpha/0.550
1yc34BCHeat shock protein HSP 90-alpha/0.528
2ccu2D9Heat shock protein HSP 90-alpha/0.526
4awq592Heat shock protein HSP 90-alpha/0.526
2ye42FYHeat shock protein HSP 90-alpha/0.523
2werRDCATP-dependent molecular chaperone HSP82/0.519
2yjwYJWHeat shock protein HSP 90-alpha/0.518
4jqlVJ6Heat shock protein HSP 90-alpha/0.515
1osfKOSHeat shock protein HSP 90-alpha/0.506
3hyz42CHeat shock protein HSP 90-alpha/0.505
4bqg50QHeat shock protein HSP 90-alpha/0.505
3ft5MO8Heat shock protein HSP 90-alpha/0.504
2xjjL81Heat shock protein HSP 90-alpha/0.502
3r4oFU3Heat shock protein HSP 90-alpha/0.501
1yetGDMHeat shock protein HSP 90-alpha/0.500
2qg0A94Heat shock protein HSP 90-alpha/0.499
3vhaVHAHeat shock protein HSP 90-alpha/0.497
4xclAGSHeat shock cognate 90 kDa protein/0.495
2xabVHDHeat shock protein HSP 90-alpha/0.494
2xhtC0YHeat shock protein HSP 90-alpha/0.493
1yc14BCHeat shock protein HSP 90-alpha/0.490
2yegXQGHeat shock protein HSP 90-alpha/0.489
4ipeANPTNF receptor-associated protein 1/0.487
4xcjADPHeat shock cognate 90 kDa protein/0.482
3k99PFTHeat shock protein HSP 90-alpha/0.480
3q5lKX2Heat shock protein 83-1/0.476
2yi7BZ8Heat shock protein HSP 90-alpha/0.470
4xdmGDMHeat shock cognate 90 kDa protein/0.468
2xx213CATP-dependent molecular chaperone HSP82/0.467
2wi2ZZ3Heat shock protein HSP 90-alpha/0.465
2xjxXJXHeat shock protein HSP 90-alpha/0.465
3ekrPY9Heat shock protein HSP 90-alpha/0.465
3k974CDHeat shock protein HSP 90-alpha/0.465
4bqjXKLHeat shock protein HSP 90-alpha/0.465
2byh2D7Heat shock protein HSP 90-alpha/0.463
2wi6ZZ6Heat shock protein HSP 90-alpha/0.463
2byi2DDHeat shock protein HSP 90-alpha/0.461
2yee2ECHeat shock protein HSP 90-alpha/0.460
1uyePU9Heat shock protein HSP 90-alpha/0.458
2yjxYJXHeat shock protein HSP 90-alpha/0.457
4as94QSATP-dependent molecular chaperone HSP82/0.456
3ekoPYUHeat shock protein HSP 90-alpha/0.455
2bz5AB4Heat shock protein HSP 90-alpha/0.453
3hhu819Heat shock protein HSP 90-alpha/0.453
1yc443PHeat shock protein HSP 90-alpha/0.452
3rlq3RQHeat shock protein HSP 90-alpha/0.450
4egkRDCHeat shock protein HSP 90-alpha/0.449
3d0bSNXHeat shock protein HSP 90-alpha/0.447
3k981RCHeat shock protein HSP 90-alpha/0.446
1uy7PU4Heat shock protein HSP 90-alpha/0.445
2bt0CT5Heat shock protein HSP 90-alpha/0.445
2qfoA13Heat shock protein HSP 90-alpha/0.445
3iedAN2HSP90/0.442
4hy6FJ1Heat shock protein HSP 90-alpha/0.442