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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2tscCB3Thymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2tscCB3Thymidylate synthase/1.000
1jutLYDThymidylate synthase/0.567
1kceCB3Thymidylate synthase/0.533
1aiqCB3Thymidylate synthase/0.528
1tduCB3Thymidylate synthase/0.522
1dnaCB3Thymidylate synthase/0.519
1kzjCB3Thymidylate synthase/0.518
2kceD16Thymidylate synthase/0.516
1kziTHGThymidylate synthase/0.512
1nceCB3Thymidylate synthase/0.505
1zprCB3Thymidylate synthase/0.504
1fwmCB3Thymidylate synthase/0.503
2bbqPFGThymidylate synthase/0.494
1axwMTXThymidylate synthase/0.488
1jtuLYBThymidylate synthase/0.482
1jtqLY3Thymidylate synthase/0.480
3bhlTHGThymidylate synthase/0.477
1tduDURThymidylate synthase/0.475
1f4fTP3Thymidylate synthase/0.473
1hvyD16Thymidylate synthase2.1.1.450.473
3bgxMEFThymidylate synthase/0.473
1dduCB3Thymidylate synthase/0.467
1jujLYAThymidylate synthase2.1.1.450.463
1bq1CB3Thymidylate synthase/0.462
1ju6LYAThymidylate synthase2.1.1.450.461
1dduDDUThymidylate synthase/0.457
1f4gTP4Thymidylate synthase/0.456
2ftoCB3Thymidylate synthase/0.452
4fogC2FThymidylate synthase ThyA/0.450
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
4knzCB3Thymidylate synthase/0.448
4fqsLYAThymidylate synthase ThyA/0.446