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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pmlANPUncharacterized protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pmlANPUncharacterized protein/1.000
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.486
2pmoHMDProtein kinase 7/0.486
3r9dX6BCyclin-dependent kinase 22.7.11.220.486
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.480
2pmnK51Protein kinase 7/0.459
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.459
2iw84SPCyclin-dependent kinase 22.7.11.220.455
4i3zADPCyclin-dependent kinase 22.7.11.220.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
1jstATPCyclin-dependent kinase 22.7.11.220.449
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.448
2w05FRTCyclin-dependent kinase 22.7.11.220.447
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4qmpDKISerine/threonine-protein kinase 242.7.11.10.445
4bgg844Activin receptor type-12.7.11.300.443
5e92ANPTGF-beta receptor type-22.7.11.300.442
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.441
2pz5ACPFibroblast growth factor receptor 2/0.441