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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdxZSTAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pdxZSTAldose reductase1.1.1.211.000
2fz9ZSTAldose reductase1.1.1.210.670
2hv5ZSTAldose reductase1.1.1.210.636
2dv0ZSTAldose reductase1.1.1.210.606
2pdu393Aldose reductase1.1.1.210.588
3m4h388Aldose reductase1.1.1.210.576
2pdg47DAldose reductase1.1.1.210.575
2fz8ZSTAldose reductase1.1.1.210.574
2hvnZSTAldose reductase1.1.1.210.559
3lboLDTAldose reductase1.1.1.210.547
1ieiZESAldose reductase1.1.1.210.545
3lqlLDTAldose reductase1.1.1.210.544
4gca2X9Aldose reductase1.1.1.210.541
3mb9ZSTAldose reductase1.1.1.210.538
1z8962PAldose reductase1.1.1.210.526
3ghuLDTAldose reductase1.1.1.210.526
2pdp393Aldose reductase1.1.1.210.522
3lz5LDTAldose reductase1.1.1.210.516
3m64393Aldose reductase1.1.1.210.516
2pdmZSTAldose reductase1.1.1.210.514
2hvoZSTAldose reductase1.1.1.210.513
2fzdTOLAldose reductase1.1.1.210.512
1z3n3NAAldose reductase1.1.1.210.509
1t40ID5Aldose reductase1.1.1.210.507
1t41ID5Aldose reductase1.1.1.210.505
4yu153NAldose reductase1.1.1.210.494
1us0LDTAldose reductase1.1.1.210.489
2ikj393Aldose reductase1.1.1.210.489
3ghsLDTAldose reductase1.1.1.210.485
2i16LDTAldose reductase1.1.1.210.484
3m0iZSTAldose reductase1.1.1.210.484
2duxZSTAldose reductase1.1.1.210.483
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.481
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.476
2pzn393Aldose reductase1.1.1.210.475
2pdh47DAldose reductase1.1.1.210.474
3ghrLDTAldose reductase1.1.1.210.474
2pdbZSTAldose reductase1.1.1.210.472
2iki388Aldose reductase1.1.1.210.470
2pdfZSTAldose reductase1.1.1.210.468
3lenZSTAldose reductase1.1.1.210.468
2pd5ZSTAldose reductase1.1.1.210.467
3t423T4Aldose reductase1.1.1.210.467
2qxwLDTAldose reductase1.1.1.210.465
2i17LDTAldose reductase1.1.1.210.464
3ghtLDTAldose reductase1.1.1.210.463
1pwlBFIAldose reductase1.1.1.210.460
2ikhLITAldose reductase1.1.1.210.460
2pdc393Aldose reductase1.1.1.210.460
2pdyFIDAldose reductase1.1.1.210.460
3ld5LDTAldose reductase1.1.1.210.460
3g5eQ74Aldose reductase1.1.1.210.458
2iqdLPAAldose reductase1.1.1.210.452
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
1frbZSTAldose reductase-related protein 2/0.451
2f2kTGGAldose reductase1.1.1.210.451
3mc5393Aldose reductase1.1.1.210.447
4ey6GNTAcetylcholinesterase3.1.1.70.446
2pdn47DAldose reductase1.1.1.210.444
4j7hTRHPCZA361.3/0.443
3mjrAC2Deoxycytidine kinase2.7.1.740.440