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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdu393Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pdu393Aldose reductase1.1.1.211.000
2pdfZSTAldose reductase1.1.1.210.616
2pdxZSTAldose reductase1.1.1.210.603
2fz8ZSTAldose reductase1.1.1.210.596
2fz9ZSTAldose reductase1.1.1.210.583
1ieiZESAldose reductase1.1.1.210.559
2hv5ZSTAldose reductase1.1.1.210.540
2pdg47DAldose reductase1.1.1.210.535
2f2kTGGAldose reductase1.1.1.210.531
2pdyFIDAldose reductase1.1.1.210.525
2dv0ZSTAldose reductase1.1.1.210.520
2pdp393Aldose reductase1.1.1.210.516
2pdq47DAldose reductase1.1.1.210.516
2iqdLPAAldose reductase1.1.1.210.514
1t40ID5Aldose reductase1.1.1.210.510
2inzOHPAldose reductase1.1.1.210.510
4gca2X9Aldose reductase1.1.1.210.509
3ld5LDTAldose reductase1.1.1.210.502
3mb9ZSTAldose reductase1.1.1.210.499
2pdmZSTAldose reductase1.1.1.210.497
1z3n3NAAldose reductase1.1.1.210.496
1z8962PAldose reductase1.1.1.210.496
3ghrLDTAldose reductase1.1.1.210.494
2i17LDTAldose reductase1.1.1.210.493
2iki388Aldose reductase1.1.1.210.487
3ghtLDTAldose reductase1.1.1.210.487
3ghuLDTAldose reductase1.1.1.210.487
3lqlLDTAldose reductase1.1.1.210.487
2pzn393Aldose reductase1.1.1.210.485
3lboLDTAldose reductase1.1.1.210.484
2i16LDTAldose reductase1.1.1.210.482
2pdh47DAldose reductase1.1.1.210.482
3ghsLDTAldose reductase1.1.1.210.481
2pdj393Aldose reductase1.1.1.210.479
3m64393Aldose reductase1.1.1.210.478
1t41ID5Aldose reductase1.1.1.210.477
3m4h388Aldose reductase1.1.1.210.477
3t423T4Aldose reductase1.1.1.210.474
2qxwLDTAldose reductase1.1.1.210.471
2fzdTOLAldose reductase1.1.1.210.469
2hvoZSTAldose reductase1.1.1.210.468
2pdbZSTAldose reductase1.1.1.210.467
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.466
3g5eQ74Aldose reductase1.1.1.210.466
2ikj393Aldose reductase1.1.1.210.465
2pdiZSTAldose reductase1.1.1.210.463
2duxZSTAldose reductase1.1.1.210.462
2duzZSTAldose reductase1.1.1.210.462
2hvnZSTAldose reductase1.1.1.210.462
2pdn47DAldose reductase1.1.1.210.461
4yu153NAldose reductase1.1.1.210.461
1us0LDTAldose reductase1.1.1.210.460
3lz5LDTAldose reductase1.1.1.210.457
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.455
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.445
2agtFIDAldose reductase1.1.1.210.444
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.442
2pdlTOLAldose reductase1.1.1.210.441