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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2oliIOPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.41.000
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.685
2othNIMBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.658
3fo7IMNPhospholipase A2 VRV-PL-VIIIa/0.578
1skgVAL_ALA_PHE_ARG_SERBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.533
1th6OINBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.532
2oyfIACBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.530
5p2pDHGPhospholipase A2, major isoenzyme3.1.1.40.530
4hmbPZZPhospholipase A2 VRV-PL-VIIIa/0.528
4qerSTLPhospholipase A2 VRV-PL-VIIIa/0.521
2pwsIBPBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.517
4eixNIMPhospholipase A2 VRV-PL-VIIIa/0.515
1dcyI3NPhospholipase A2, membrane associated/0.497
2qvdBERBasic phospholipase A2 VRV-PL-VIIIa3.1.1.40.480
1db56INPhospholipase A2, membrane associated/0.475
4n3r2GUTankyrase-12.4.2.300.472
1kquBR4Phospholipase A2, membrane associated/0.455
1aypINBPhospholipase A2, membrane associated/0.453
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.452
3u8dU8DPhospholipase A2, membrane associated/0.449
4eevL1XHepatocyte growth factor receptor2.7.10.10.449
1db48INPhospholipase A2, membrane associated/0.445
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
1v79FR7Adenosine deaminase3.5.4.40.440
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.440