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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jaeFADL-amino acid oxidase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2jaeFADL-amino acid oxidase/1.000
5g3tFDAFlavin-dependent L-tryptophan oxidase VioA/0.562
3bi2FADPolyamine oxidase FMS1/0.524
4gdpFADPolyamine oxidase FMS1/0.519
1f8sFADL-amino-acid oxidase1.4.3.20.515
2yg5FADPutrescine oxidase/0.511
2hkoFADLysine-specific histone demethylase 1A10.508
3cndFADPolyamine oxidase FMS1/0.498
1xpqFADPolyamine oxidase FMS1/0.481
3cn8FADPolyamine oxidase FMS1/0.479
2e1mFADL-glutamate oxidase/0.472
3we0FADLysine 2-monooxygenase/0.472
1f8rFADL-amino-acid oxidase1.4.3.20.461
4echFADPolyamine oxidase FMS1/0.461
3kpfFADPolyamine oxidase1.5.3.140.458
3rhaFDAPutrescine oxidase/0.457
3bi5FADPolyamine oxidase FMS1/0.454
2iw5FADLysine-specific histone demethylase 1A10.453
5l3dFADLysine-specific histone demethylase 1A10.452
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.451
2yg4FADPutrescine oxidase/0.449
1hb1OCVIsopenicillin N synthase1.21.3.10.448
4fwjFADLysine-specific histone demethylase 1B10.447
3cntFADPolyamine oxidase FMS1/0.446
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.445
3zdnFADMonoamine oxidase N1.4.3.40.443
1qo8FADFumarate reductase flavoprotein subunit/0.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
4q71FADBifunctional protein PutA/0.441
3k7tFAD6-hydroxy-L-nicotine oxidase/0.440