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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iejS48Protein farnesyltransferase subunit beta2.5.1.58

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2iejS48Protein farnesyltransferase subunit beta2.5.1.581.000
1sa4JANProtein farnesyltransferase subunit beta2.5.1.580.825
1ld7U66Protein farnesyltransferase subunit beta2.5.1.580.739
1mzcBNEProtein farnesyltransferase subunit beta2.5.1.580.705
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.696
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.676
3e33ED7Protein farnesyltransferase subunit beta2.5.1.580.668
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.667
3ksqZ96Protein farnesyltransferase subunit beta2.5.1.580.653
2f0y3MNProtein farnesyltransferase subunit beta2.5.1.580.646
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.638
1o1s1NHProtein farnesyltransferase subunit beta2.5.1.580.636
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.627
1s63778Protein farnesyltransferase subunit beta2.5.1.580.624
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.623
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.619
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.619
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.618
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.618
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.618
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.618
3sfy3FYUncharacterized protein/0.617
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.615
3q7fED2Uncharacterized protein/0.604
3kslSZHProtein farnesyltransferase subunit beta2.5.1.580.554
3e30ED4Protein farnesyltransferase subunit beta2.5.1.580.545
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.543
3pz43PZProtein farnesyltransferase subunit beta2.5.1.580.533
4gtv7TRGeranylgeranyl transferase type-2 subunit beta2.5.1.600.509
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.498
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.483
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.475
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.457
1x1bSAHC-20 methyltransferase/0.451
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.450
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.442