scPDB - Distribution of Cavity Similarity values of 2hv5 entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2hv5	ZST	Aldose reductase	1.1.1.21

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2hv5	ZST	Aldose reductase	1.1.1.21	1.000
2dv0	ZST	Aldose reductase	1.1.1.21	0.806
2fz9	ZST	Aldose reductase	1.1.1.21	0.777
2fz8	ZST	Aldose reductase	1.1.1.21	0.709
2pdx	ZST	Aldose reductase	1.1.1.21	0.708
3mb9	ZST	Aldose reductase	1.1.1.21	0.645
1t40	ID5	Aldose reductase	1.1.1.21	0.643
1z3n	3NA	Aldose reductase	1.1.1.21	0.642
3m4h	388	Aldose reductase	1.1.1.21	0.635
1z89	62P	Aldose reductase	1.1.1.21	0.633
2i16	LDT	Aldose reductase	1.1.1.21	0.629
3ghu	LDT	Aldose reductase	1.1.1.21	0.622
3g5e	Q74	Aldose reductase	1.1.1.21	0.621
3m64	393	Aldose reductase	1.1.1.21	0.619
3lql	LDT	Aldose reductase	1.1.1.21	0.611
3lbo	LDT	Aldose reductase	1.1.1.21	0.607
2ikj	393	Aldose reductase	1.1.1.21	0.602
4gca	2X9	Aldose reductase	1.1.1.21	0.602
1us0	LDT	Aldose reductase	1.1.1.21	0.601
2pdu	393	Aldose reductase	1.1.1.21	0.600
2qxw	LDT	Aldose reductase	1.1.1.21	0.593
3ghr	LDT	Aldose reductase	1.1.1.21	0.589
2pdh	47D	Aldose reductase	1.1.1.21	0.584
2pdp	393	Aldose reductase	1.1.1.21	0.579
1iei	ZES	Aldose reductase	1.1.1.21	0.576
2pdg	47D	Aldose reductase	1.1.1.21	0.576
2ikh	LIT	Aldose reductase	1.1.1.21	0.575
1t41	ID5	Aldose reductase	1.1.1.21	0.572
2hvo	ZST	Aldose reductase	1.1.1.21	0.572
2pdf	ZST	Aldose reductase	1.1.1.21	0.568
1pwl	BFI	Aldose reductase	1.1.1.21	0.565
3ghs	LDT	Aldose reductase	1.1.1.21	0.565
2iki	388	Aldose reductase	1.1.1.21	0.563
2pd5	ZST	Aldose reductase	1.1.1.21	0.563
2pdb	ZST	Aldose reductase	1.1.1.21	0.562
3ght	LDT	Aldose reductase	1.1.1.21	0.562
3len	ZST	Aldose reductase	1.1.1.21	0.560
3mc5	393	Aldose reductase	1.1.1.21	0.557
2pzn	393	Aldose reductase	1.1.1.21	0.556
4yu1	53N	Aldose reductase	1.1.1.21	0.556
2pdl	TOL	Aldose reductase	1.1.1.21	0.548
2i17	LDT	Aldose reductase	1.1.1.21	0.545
3t42	3T4	Aldose reductase	1.1.1.21	0.545
3ld5	LDT	Aldose reductase	1.1.1.21	0.540
3lz5	LDT	Aldose reductase	1.1.1.21	0.539
2fzd	TOL	Aldose reductase	1.1.1.21	0.537
2pdc	393	Aldose reductase	1.1.1.21	0.535
2pfh	NDP	Aldose reductase	1.1.1.21	0.534
3m0i	ZST	Aldose reductase	1.1.1.21	0.527
2pdn	47D	Aldose reductase	1.1.1.21	0.526
2duz	ZST	Aldose reductase	1.1.1.21	0.520
2dux	ZST	Aldose reductase	1.1.1.21	0.515
1frb	ZST	Aldose reductase-related protein 2	/	0.500
2pdq	47D	Aldose reductase	1.1.1.21	0.489
1ah3	TOL	Aldose reductase	1.1.1.21	0.476
3mjr	AC2	Deoxycytidine kinase	2.7.1.74	0.470
2inz	OHP	Aldose reductase	1.1.1.21	0.467
2pdw	FID	Aldose reductase	1.1.1.21	0.467
2pdy	FID	Aldose reductase	1.1.1.21	0.467
2iqd	LPA	Aldose reductase	1.1.1.21	0.466
3g49	3G4	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.466
4ey6	GNT	Acetylcholinesterase	3.1.1.7	0.464
3aiv	HBO	4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic	3.2.1.182	0.463
2c1z	KMP	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.460
3hl0	NAD	Maleylacetate reductase	/	0.458
1zgb	A1E	Acetylcholinesterase	3.1.1.7	0.457
2xi4	AFT	Acetylcholinesterase	3.1.1.7	0.455
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.454
1zgc	A2E	Acetylcholinesterase	3.1.1.7	0.454
2aot	2PM	Histamine N-methyltransferase	2.1.1.8	0.454
4e0u	0MV	Cyclic dipeptide N-prenyltransferase	/	0.454
2f2k	TGG	Aldose reductase	1.1.1.21	0.453
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.451
4mt9	2D6	Tankyrase-1	2.4.2.30	0.451
2xuq	TZ4	Acetylcholinesterase	3.1.1.7	0.450
1ut6	A8N	Acetylcholinesterase	3.1.1.7	0.449
1el3	I84	Aldose reductase	1.1.1.21	0.448
1c7o	PPG	Hemolysin	/	0.447
2hzq	STR	Apolipoprotein D	/	0.447
2qjp	ANJ	Cytochrome b	/	0.447
2zi5	3L1	Deoxycytidine kinase	2.7.1.74	0.447
4pnm	NU1	Tankyrase-2	2.4.2.30	0.447
4jt8	1NR	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.446
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.445
2agt	FID	Aldose reductase	1.1.1.21	0.445
4k4e	K4E	Tankyrase-1	2.4.2.30	0.445
2aov	C2M	Histamine N-methyltransferase	2.1.1.8	0.444
2d06	EST	Sulfotransferase 1A1	2.8.2.1	0.444
2c1z	U2F	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.443
3r43	ID8	Aldo-keto reductase family 1 member C3	/	0.443
4j7h	TRH	PCZA361.3	/	0.443
4pnr	G18	Tankyrase-2	2.4.2.30	0.443
3tfu	PL8	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase	2.6.1.62	0.442
1fap	RAP	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.441
1fap	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.441
1u65	CP0	Acetylcholinesterase	3.1.1.7	0.441
3k4s	0MO	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.441
3pn1	IVH	DNA ligase	/	0.441
4a32	2CD	Glycylpeptide N-tetradecanoyltransferase	/	0.440
4bj9	UHB	Tankyrase-2	2.4.2.30	0.440
4dbw	511	Aldo-keto reductase family 1 member C3	/	0.440