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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hchN5AEndoplasmin

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2hchN5AEndoplasmin/1.000
2gqpPA7Endoplasmin/0.642
2fypRDEEndoplasmin/0.556
2exlGDMEndoplasmin/0.508
1u2oNECEndoplasmin/0.506
1u0zRDCEndoplasmin/0.503
1yszNECEndoplasmin/0.503
2gfdRDAEndoplasmin/0.500
3rlq3RQHeat shock protein HSP 90-alpha/0.498
2hg1N5OEndoplasmin/0.495
3ekrPY9Heat shock protein HSP 90-alpha/0.489
4fcr0TMHeat shock protein HSP 90-alpha/0.486
1qy8RDIEndoplasmin/0.478
3rlr3RRHeat shock protein HSP 90-alpha/0.476
3r4pFU7Heat shock protein HSP 90-alpha/0.475
4bqjXKLHeat shock protein HSP 90-alpha/0.471
4xc0ACPHeat shock cognate 90 kDa protein/0.468
2yefANPHeat shock protein HSP 90-alpha/0.465
1qy5NECEndoplasmin/0.462
1u0yPA7Endoplasmin/0.461
2yegXQGHeat shock protein HSP 90-alpha/0.461
2iwuNP5ATP-dependent molecular chaperone HSP82/0.460
3t0zATPHeat shock protein HSP 90-alpha/0.457
3k981RCHeat shock protein HSP 90-alpha/0.456
2breKJ2ATP-dependent molecular chaperone HSP82/0.453
3r4nFU5Heat shock protein HSP 90-alpha/0.453
2wepADPATP-dependent molecular chaperone HSP82/0.448
2xx213CATP-dependent molecular chaperone HSP82/0.446
4gqtADPHeat shock protein 90/0.444
3whaWHAHeat shock protein HSP 90-alpha/0.442
1byqADPHeat shock protein HSP 90-alpha/0.441
3t10ACPHeat shock protein HSP 90-alpha/0.441