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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fgiPD1Fibroblast growth factor receptor 1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2fgiPD1Fibroblast growth factor receptor 1/1.000
3js2VM1Fibroblast growth factor receptor 1/0.520
4nka2K7Fibroblast growth factor receptor 1/0.503
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.498
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.484
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.475
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.471
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.471
4f640S8Fibroblast growth factor receptor 1/0.471
4nks2M2Fibroblast growth factor receptor 1/0.471
4nk92K5Fibroblast growth factor receptor 1/0.458
3bu5ATPInsulin receptor2.7.10.10.455
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4j97ACPFibroblast growth factor receptor 2/0.450
4btkDTQTau-tubulin kinase 12.7.11.10.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.445
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.443
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.440