scPDB - Distribution of Cavity Similarity values of 2f2k entry / Site 1

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2f2k	TGG	Aldose reductase	1.1.1.21

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity
2f2k	TGG	Aldose reductase	1.1.1.21	1.000
2pdy	FID	Aldose reductase	1.1.1.21	0.662
2inz	OHP	Aldose reductase	1.1.1.21	0.653
2iqd	LPA	Aldose reductase	1.1.1.21	0.644
3u2c	SUZ	Aldose reductase	1.1.1.21	0.636
1az2	NAP	Aldose reductase	1.1.1.21	0.595
2pdu	393	Aldose reductase	1.1.1.21	0.579
2fz8	ZST	Aldose reductase	1.1.1.21	0.558
3v35	NTI	Aldose reductase	1.1.1.21	0.556
3s3g	TLT	Aldose reductase	1.1.1.21	0.546
3q67	NAP	Aldose reductase	1.1.1.21	0.543
2pdw	FID	Aldose reductase	1.1.1.21	0.523
1ef3	FID	Aldose reductase	1.1.1.21	0.522
2nvc	ITA	Aldose reductase	1.1.1.21	0.519
2pdk	SBI	Aldose reductase	1.1.1.21	0.519
2pdx	ZST	Aldose reductase	1.1.1.21	0.513
3p2v	DOY	Aldose reductase	1.1.1.21	0.511
2pd9	FID	Aldose reductase	1.1.1.21	0.506
2is7	2CL	Aldose reductase	1.1.1.21	0.502
1iei	ZES	Aldose reductase	1.1.1.21	0.501
1pwm	FID	Aldose reductase	1.1.1.21	0.498
2pdg	47D	Aldose reductase	1.1.1.21	0.498
2pdj	393	Aldose reductase	1.1.1.21	0.498
4gab	FID	Aldo-keto reductase family 1 member B10	1.1.1	0.498
2fz9	ZST	Aldose reductase	1.1.1.21	0.494
1eko	I84	Aldose reductase	1.1.1.21	0.493
5liu	388	Aldo-keto reductase family 1 member B10	1.1.1	0.493
2agt	FID	Aldose reductase	1.1.1.21	0.491
1ah0	SBI	Aldose reductase	1.1.1.21	0.482
2pdf	ZST	Aldose reductase	1.1.1.21	0.482
3ghs	LDT	Aldose reductase	1.1.1.21	0.480
2pdm	ZST	Aldose reductase	1.1.1.21	0.478
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.471
4wev	SUZ	Aldo-keto reductase family 1 member B10	1.1.1	0.468
1el3	I84	Aldose reductase	1.1.1.21	0.467
1z89	62P	Aldose reductase	1.1.1.21	0.466
3ghr	LDT	Aldose reductase	1.1.1.21	0.466
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.465
2pdp	393	Aldose reductase	1.1.1.21	0.462
2iki	388	Aldose reductase	1.1.1.21	0.461
2hv5	ZST	Aldose reductase	1.1.1.21	0.460
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.460
4gca	2X9	Aldose reductase	1.1.1.21	0.460
3ght	LDT	Aldose reductase	1.1.1.21	0.459
4yu1	53N	Aldose reductase	1.1.1.21	0.457
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.455
2i17	LDT	Aldose reductase	1.1.1.21	0.454
2hej	NDP	Aldo-keto reductase family 1 member C21	1.1.1	0.453
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.452
2pzn	393	Aldose reductase	1.1.1.21	0.451
3mb9	ZST	Aldose reductase	1.1.1.21	0.451
2cbq	TH2	Neocarzinostatin	/	0.450
2dv0	ZST	Aldose reductase	1.1.1.21	0.449
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.447
1t40	ID5	Aldose reductase	1.1.1.21	0.447
2hvo	ZST	Aldose reductase	1.1.1.21	0.447
3fvu	IAC	Kynurenine--oxoglutarate transaminase 1	2.6.1.7	0.447
3zv7	NHG	Acetylcholinesterase	3.1.1.7	0.447
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.445
2fzd	TOL	Aldose reductase	1.1.1.21	0.445
2xuo	TZ4	Acetylcholinesterase	3.1.1.7	0.445
2y6f	M9F	Isopenicillin N synthase	1.21.3.1	0.444
1xl8	152	Peroxisomal carnitine O-octanoyltransferase	2.3.1.137	0.443
2pdi	ZST	Aldose reductase	1.1.1.21	0.443
4ga8	SBI	Aldo-keto reductase family 1 member B10	1.1.1	0.443
1uho	VDN	cGMP-specific 3',5'-cyclic phosphodiesterase	/	0.442
1x1a	SAM	C-20 methyltransferase	/	0.442
2g5w	8PG	12-oxophytodienoate reductase 3	1.3.1.42	0.442
3u57	DH8	Raucaffricine-O-beta-D-glucosidase	3.2.1.125	0.442
4a32	2CD	Glycylpeptide N-tetradecanoyltransferase	/	0.442
4c2z	646	Glycylpeptide N-tetradecanoyltransferase 1	/	0.441
3lbo	LDT	Aldose reductase	1.1.1.21	0.440
3lql	LDT	Aldose reductase	1.1.1.21	0.440
3m4h	388	Aldose reductase	1.1.1.21	0.440