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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2clhF19Tryptophan synthase alpha chain

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2clhF19Tryptophan synthase alpha chain/1.000
1a50FIPTryptophan synthase alpha chain/0.614
4xugF9FTryptophan synthase alpha chain/0.597
2trsIPLTryptophan synthase alpha chain/0.596
1fuyFIPTryptophan synthase alpha chain/0.574
1a5sFIPTryptophan synthase alpha chain/0.571
2clfF6FTryptophan synthase alpha chain/0.565
4y6gF6FTryptophan synthase alpha chain/0.561
1k8zIAGTryptophan synthase alpha chain/0.560
1k8y13PTryptophan synthase alpha chain/0.545
2rh9IGPTryptophan synthase alpha chain/0.531
1qoqIGPTryptophan synthase alpha chain/0.511
1kfbIGPTryptophan synthase alpha chain/0.495
4zqcF6FTryptophan synthase alpha chain/0.480
1beuIPLTryptophan synthase alpha chain/0.479
1fmjRTLRetinol dehydratase/0.474
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.471
1k7fIAVTryptophan synthase alpha chain/0.467
3h3r14HCollagen type IV alpha-3-binding protein/0.466
2ociTYCValacyclovir hydrolase3.10.464
5jlaNADPutative short-chain dehydrogenase/reductase/0.463
4qa0SHHHistone deacetylase 83.5.1.980.461
1kfcIPLTryptophan synthase alpha chain/0.460
3njoPYVAbscisic acid receptor PYR1/0.459
2acwUPGGlycosyltransferase/0.458
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.457
2om9AJAPeroxisome proliferator-activated receptor gamma/0.457
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.456
5bp9SAHPutative methyltransferase protein/0.455
1a5bIGPTryptophan synthase alpha chain/0.454
1w22NHBHistone deacetylase 83.5.1.980.454
4wx2F6FTryptophan synthase alpha chain/0.453
4wx2F6FTryptophan synthase beta chain4.2.1.200.453
1jumBERHTH-type transcriptional regulator QacR/0.450
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.450
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3jq8DX3Pteridine reductase, putative/0.450
1fmlRTLRetinol dehydratase/0.449
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.449
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.448
4qa2SHHHistone deacetylase 83.5.1.980.448
3nxyD2HDihydrofolate reductase1.5.1.30.447
2mm3CHOGastrotropin/0.446
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.445
2in6839Wee1-like protein kinase2.7.10.20.444
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.444
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.444
1rsgFADPolyamine oxidase FMS1/0.443
3h3t16HCollagen type IV alpha-3-binding protein/0.443
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
1towCRZFatty acid-binding protein, adipocyte/0.442
4g8bHL6Alpha/beta hydrolase fold protein/0.442
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.441
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.441
2cleF6FTryptophan synthase alpha chain/0.440
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.440
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.440
4z9rNADOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.440