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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2aoe0Q4Gag-Pol polyprotein3.4.23.16

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2aoe0Q4Gag-Pol polyprotein3.4.23.161.000
2ieo017Protease/0.629
4njvRITProtease/0.623
2nnkROCProtease/0.621
2f81017Gag-Pol polyprotein3.4.23.160.619
4hdfG52Gag-Pol polyprotein3.4.23.160.613
3a2oKNJGag-Pol polyprotein3.4.23.160.604
2pk5075Protease/0.600
3em4DR7Gag-Pol polyprotein3.4.23.160.600
3ggaGGWGag-Pol polyprotein/0.592
1hvjA78Gag-Pol polyprotein/0.591
2f80017Gag-Pol polyprotein3.4.23.160.590
1rl8RITGag-Pol polyprotein3.4.23.160.588
4rvj478Protease/0.585
1difA85Gag-Pol polyprotein/0.582
4kb9G79Protease/0.581
2idw017Protease/0.580
3kf03TLGag-Pol polyprotein/0.578
3pwrROCGag-Pol polyprotein3.4.23.160.575
1sdvMK1Gag-Pol polyprotein3.4.23.160.574
2xyfG40Gag-Pol polyprotein/0.573
3ekp478Gag-Pol polyprotein3.4.23.160.573
3zpsEQMGag-Pol polyprotein3.4.23.160.573
2qd8065Gag-Pol polyprotein3.4.23.160.572
2cem2AHPol protein/0.571
3linE13Protease/0.570
2qd6065Gag-Pol polyprotein3.4.23.160.568
4njuTPVProtease/0.567
2nmyROCProtease/0.566
2uy0HV1Gag-Pol polyprotein3.4.23.160.566
3jvy017Gag-Pol polyprotein3.4.23.160.566
3tl9ROCGag-Pol polyprotein3.4.23.160.565
1ec2BEJGag-Pol polyprotein3.4.23.160.564
3k4vROCGag-Pol polyprotein3.4.23.160.564
3kdcJZPGag-Pol polyprotein3.4.23.160.562
3ndtROCGag-Pol polyprotein3.4.23.160.562
1ivp1ZKGag-Pol polyprotein/0.561
3ndwRITGag-Pol polyprotein3.4.23.160.561
1hvsA77Gag-Pol polyprotein/0.560
2p3b3TLV-1 PROTEASE protein/0.560
2p3b3TLV-1 protease/0.560
4djoMK5Pol polyprotein/0.560
3ok9G52Gag-Pol polyprotein3.4.23.160.557
4a4qUX9Pol protein/0.557
2aquDR7Gag-Pol polyprotein3.4.23.160.554
1hxbROCGag-Pol polyprotein3.4.23.160.553
1dw60Q4Gag-Pol polyprotein3.4.23.160.551
2i4dQFIProtease/0.551
2pk6O33V-1 protease/0.551
3hzc2NCProtease/0.551
1hvkA79Gag-Pol polyprotein/0.550
2bqvA1AProtease/0.550
3ndxRITGag-Pol polyprotein3.4.23.160.550
4hdbG52Gag-Pol polyprotein3.4.23.160.549
3ggxGGXGag-Pol polyprotein/0.548
1zsr0ZTGag-Pol polyprotein3.4.23.160.547
2i4uDJRProtease/0.547
2i4wKGQProtease/0.547
3ekqROCGag-Pol polyprotein3.4.23.160.547
4hegG52Gag-Pol polyprotein3.4.23.160.547
3zptM8YGag-Pol polyprotein3.4.23.160.546
1hvlA76Gag-Pol polyprotein/0.545
1w5yBE6Gag-Pol polyprotein3.4.23.160.545
2rkfAB1Pol protein/0.544
2xyeCXGGag-Pol polyprotein/0.544
3dk1G05Gag-Pol polyprotein3.4.23.160.544
3st5G89Gag-Pol polyprotein3.4.23.160.544
1ffi2NCGag-Pol polyprotein3.4.23.160.543
3fx5KNIGag-Pol polyprotein3.4.23.160.543
2i4xKGQProtease/0.542
3qn8NI7Gag-Pol polyprotein3.4.23.160.542
1d4yTPVGag-Pol polyprotein3.4.23.160.541
1hiv1ZKGag-Pol polyprotein/0.541
3nuo478Gag-Pol polyprotein3.4.23.160.541
1ec3MS3Gag-Pol polyprotein3.4.23.160.540
1fg62NCGag-Pol polyprotein3.4.23.160.540
3kfr3TLGag-Pol polyprotein/0.540
3nyg2NCGag-Pol polyprotein3.4.23.160.540
3oxcROCProtease/0.540
1k2b0Q4Gag-Pol polyprotein3.4.23.160.539
3kfn3TLGag-Pol polyprotein/0.538
2a1eIPFGag-Pol polyprotein3.4.23.160.537
2wl05AHGag-Pol polyprotein/0.537
3kddJZQGag-Pol polyprotein3.4.23.160.537
2cen4AHProtease/0.536
2fxeDR7Gag-Pol polyprotein3.4.23.160.536
1k1u0Q4Gag-Pol polyprotein3.4.23.160.535
3sa323XProtease/0.535
2f3kRO1Protease/0.533
2uxzHI1Gag-Pol polyprotein3.4.23.160.533
3mxeK54Gag-Pol polyprotein3.4.23.160.533
1ohr1UNV-1 PROTEASE protein/0.532
1sdtMK1Gag-Pol polyprotein3.4.23.160.531
2qnnQN1Gag-Pol polyprotein3.4.23.160.531
2qi3MZ5Gag-Pol polyprotein/0.530
3jw2017Gag-Pol polyprotein3.4.23.160.530
4djpM73Pol polyprotein/0.530
2bpy3INGag-Pol polyprotein3.4.23.160.528
3sa755AProtease/0.528
3sa6F71Protease/0.527
4djr0KJPol polyprotein/0.527
1bv7XV6Gag-Pol polyprotein3.4.23.160.526
3bvb017Gag-Pol polyprotein3.4.23.160.526
3nxe2NCProtease/0.526
3s56ROCProtease/0.525
3vfa031Gag-Pol polyprotein3.4.23.160.525
1iiq0ZRGag-Pol polyprotein3.4.23.160.524
1n49RITGag-Pol polyprotein3.4.23.160.524
1w5xBE5Gag-Pol polyprotein3.4.23.160.524
2q5kAB1Protease/0.524
2qi6MZ8Gag-Pol polyprotein/0.524
3cyxROCGag-Pol polyprotein3.4.23.160.524
3nduROCGag-Pol polyprotein3.4.23.160.524
3o9cK20Pol polyprotein/0.524
4qgiROCGag-Pol polyprotein3.4.23.160.524
2fdd385Pol protein/0.523
3bva2NCGag-Pol polyprotein3.4.23.160.523
3ekyDR7Gag-Pol polyprotein3.4.23.160.523
1fgc2NCGag-Pol polyprotein3.4.23.160.522
3ekt017Gag-Pol polyprotein3.4.23.160.522
3s54017Protease/0.522
2bpz3INGag-Pol polyprotein3.4.23.160.521
3liqE14Protease/0.521
3oxxDR7Gag-Pol polyprotein3.4.23.160.521
3s85LK0Gag-Pol polyprotein/0.521
3sa5A69Protease/0.521
3sabF78Protease/0.521
1vikBAYGag-Pol polyprotein/0.520
2qci065Gag-Pol polyprotein3.4.23.160.520
3vf5031Gag-Pol polyprotein3.4.23.160.520
1d4sTPVGag-Pol polyprotein3.4.23.160.519
1xl5190Gag-Pol polyprotein3.4.23.160.519
1yt9OISGag-Pol polyprotein/0.519
3o9bK2APol polyprotein/0.519
4djqM86Pol polyprotein/0.519
7upjINUGag-Pol polyprotein3.4.23.160.519
1ec1BEEGag-Pol polyprotein3.4.23.160.518
3bxsDRSGag-Pol polyprotein3.4.23.160.518
1t7i017Gag-Pol polyprotein3.4.23.160.517
2a4fAAUV-1 protease/0.517
3gi6D78Gag-Pol polyprotein/0.517
3nu9478Gag-Pol polyprotein3.4.23.160.517
3zpuM8BGag-Pol polyprotein3.4.23.160.517
1hviA77Protease/0.516
1wbmBLLPol protein/0.516
3s43478Protease/0.516
1ff02NCGag-Pol polyprotein3.4.23.160.515
3sa4F72Protease/0.515
2i4vDJRV-1 protease/0.514
2o4pTPVProtease/0.514
3nwq2NCGag-Pol polyprotein3.4.23.160.514
1vijBAYGag-Pol polyprotein/0.513
2upjU02Gag-Pol polyprotein3.4.23.160.513
3ekwDR7Gag-Pol polyprotein3.4.23.160.513
2p3d3TLProtease/0.512
3cktYDPGag-Pol polyprotein3.4.23.160.512
1a9mU0EGag-Pol polyprotein/0.511
1hxwRITGag-Pol polyprotein/0.511
2bpv1INGag-Pol polyprotein3.4.23.160.511
1hosPHPGag-Pol polyprotein/0.510
3i2l2NCProtease/0.510
4hdpG52Gag-Pol polyprotein3.4.23.160.510
1odw0E8Gag-Pol polyprotein3.4.23.160.509
2qi5MZ7Gag-Pol polyprotein/0.508
1z1hHBBGag-Pol polyprotein3.4.23.160.507
2pyn1UNGag-Pol polyprotein3.4.23.160.507
2q54MU1Protease/0.507
3d1xROCGag-Pol polyprotein3.4.23.160.507
1hsgMK1Gag-Pol polyprotein/0.506
1sbgIM1Gag-Pol polyprotein/0.506
1wbk568Pol protein/0.506
3jvwDMPGag-Pol polyprotein3.4.23.160.506
3d1yROCGag-Pol polyprotein3.4.23.160.505
3el9DR7Gag-Pol polyprotein3.4.23.160.505
3i6oGR6Gag-Pol polyprotein3.4.23.160.505
4dqe017Gag-Pol polyprotein/0.505
3em6017Gag-Pol polyprotein3.4.23.160.504
3vfb031Gag-Pol polyprotein3.4.23.160.504
2fde385Gag-Pol polyprotein3.4.23.160.503
3sa9A68Protease/0.503
2b7zMK1Gag-Pol polyprotein/0.502
1d4iBEGGag-Pol polyprotein3.4.23.160.501
1d4kPI8Gag-Pol polyprotein3.4.23.160.501
1iziQ50Gag-Pol polyprotein3.4.23.160.501
4k4p3TLGag-Pol polyprotein/0.501
2qd7065Gag-Pol polyprotein3.4.23.160.500
4ye3G04Gag-Pol polyprotein3.4.23.160.500
1ebwBEIGag-Pol polyprotein3.4.23.160.499
3el51UNGag-Pol polyprotein/0.499
3o9fK2DGag-Pol polyprotein/0.499
3qaaG04Gag-Pol polyprotein3.4.23.160.499
3qbfJHGGag-Pol polyprotein3.4.23.160.499
3sacAF8Protease/0.499
1hpoUNIGag-Pol polyprotein3.4.23.160.498
2bpw1INGag-Pol polyprotein3.4.23.160.498
2f8g017Gag-Pol polyprotein3.4.23.160.498
2p3a3TLPol protein/0.498
3gi4K60Gag-Pol polyprotein/0.498
3o9eA60Pol polyprotein/0.498
4njsG08Protease/0.498
1w5vBE3Gag-Pol polyprotein3.4.23.160.497
2qhcAB1Protease/0.497
3dcrKVSProtease/0.497
1jld0PPGag-Pol polyprotein/0.496
2aidTHKGag-Pol polyprotein3.4.23.160.496
3qrsNK8Gag-Pol polyprotein3.4.23.160.496
3tog079Gag-Pol polyprotein2.7.7.490.496
3vf7031Gag-Pol polyprotein3.4.23.160.496
4j55031Gag-Pol polyprotein3.4.23.160.496
1b6pPI7Gag-Pol polyprotein3.4.23.160.495
1mtrPI6Gag-Pol polyprotein3.4.23.160.495
1zsf0ZSGag-Pol polyprotein3.4.23.160.495
3el4ROCGag-Pol polyprotein3.4.23.160.495
3kfs3TLGag-Pol polyprotein/0.495
3qrmNK7Gag-Pol polyprotein3.4.23.160.495
1daz0Q4Gag-Pol polyprotein3.4.23.160.494
3qp0NI8Gag-Pol polyprotein3.4.23.160.494
3t113T1Gag-Pol polyprotein3.4.23.160.494
1ebzBECGag-Pol polyprotein3.4.23.160.493
1ec0BEDGag-Pol polyprotein3.4.23.160.493
2qnpQN2Gag-Pol polyprotein3.4.23.160.493
2r5pMK1Gag-Pol polyprotein/0.493
1a8k0Q4Gag-Pol polyprotein3.4.23.160.492
1hshMK1Gag-Pol polyprotein/0.492
3em3478Gag-Pol polyprotein3.4.23.160.492
2q3kMUWGag-Pol polyprotein/0.491
3el1DR7Gag-Pol polyprotein3.4.23.160.491
3saa77FProtease/0.491
4a6bQG8Gag-Pol polyprotein3.4.23.160.491
1fff0Q4Gag-Pol polyprotein3.4.23.160.490
1z1rHBHGag-Pol polyprotein3.4.23.160.490
2qi7MZ9Gag-Pol polyprotein/0.490
3t3c017Gag-Pol polyprotein3.4.23.160.490
1fej2NCGag-Pol polyprotein3.4.23.160.489
1hihC20Gag-Pol polyprotein/0.489
1m0b0ZQGag-Pol polyprotein3.4.23.160.489
2qak1UNGag-Pol polyprotein3.4.23.160.489
2qnqQN3Gag-Pol polyprotein3.4.23.160.489
3dckKVIProtease/0.489
3litE15Protease/0.489
4dqc017Gag-Pol polyprotein/0.489
1a940Q4Gag-Pol polyprotein3.4.23.160.488
1t3r017Gag-Pol polyprotein3.4.23.160.488
2wkz5AHGag-Pol polyprotein/0.488
3bgbLJGGag-Pol polyprotein3.4.23.160.488
1a8g2Z4Gag-Pol polyprotein3.4.23.160.487
1d4lPI9Gag-Pol polyprotein3.4.23.160.487
1fg80Q4Gag-Pol polyprotein3.4.23.160.487
2avvMK1Gag-Pol polyprotein3.4.23.160.487
2cej1AHPol protein/0.487
3ttp017Gag-Pol polyprotein3.4.23.160.487
1bdlIM1Gag-Pol polyprotein3.4.23.160.486
2fleAIProtease/0.486
2ien017Gag-Pol polyprotein3.4.23.160.486
2qhzMZ2Gag-Pol polyprotein/0.486
4a6cQG9Gag-Pol polyprotein3.4.23.160.485
1b6kPI5Gag-Pol polyprotein3.4.23.160.484
1b6mPI6Gag-Pol polyprotein3.4.23.160.484
1npa3NHGag-Pol polyprotein3.4.23.160.484
1npwLGZGag-Pol polyprotein3.4.23.160.484
1sduMK1Gag-Pol polyprotein3.4.23.160.484
2fxdDR7Pol polyprotein/0.484
2hb3GRLProtease/0.484
3nu4478Gag-Pol polyprotein3.4.23.160.484
1sh9RITGag-Pol polyprotein3.4.23.160.483
1t7kBH0Gag-Pol polyprotein3.4.23.160.483
3djkG55Gag-Pol polyprotein3.4.23.160.483
9hvp0E9Gag-Pol polyprotein/0.483
1sivPSIGag-Pol polyprotein/0.482
1tcxIM1Gag-Pol polyprotein3.4.23.160.482
2hc0AB2Protease/0.482
2nnpROCProtease/0.482
1ida0POGag-Pol polyprotein3.4.23.470.481
2hs2017Protease/0.481
3ekv478Gag-Pol polyprotein3.4.23.160.481
3gi5K62Gag-Pol polyprotein/0.481
3wsjMK1Protease/0.481
4njt017Protease/0.481
1muiAB1Protease/0.480
2bb9AKCGag-Pol polyprotein3.4.23.160.480
3o9iA61Gag-Pol polyprotein/0.480
1b6lPI4Gag-Pol polyprotein3.4.23.160.479
1bai0Q4Gag-Pro polyprotein/0.479
2avm2NCGag-Pol polyprotein3.4.23.160.479
2qhyMZ1Gag-Pol polyprotein/0.479
4q1y017Gag-Pol polyprotein3.4.23.160.479
1c6zROCProtease/0.478
4dqh017Gag-Pol polyprotein/0.478
1izhQ50Protease/0.477
2avsMK1Gag-Pol polyprotein3.4.23.160.477
2pqzG0GGag-Pol polyprotein3.4.23.160.477
2r5q1UNGag-Pol polyprotein/0.477
1qbrXV6Gag-Pol polyprotein3.4.23.160.476
3nu5478Gag-Pol polyprotein3.4.23.160.476
1mrwK57Gag-Pol polyprotein3.4.23.160.475
4dqb017Gag-Pol polyprotein/0.475
1ebyBEBGag-Pol polyprotein3.4.23.160.474
1kzkJE2Gag-Pol polyprotein3.4.23.160.474
3pwm017Gag-Pol polyprotein3.4.23.160.474
1bdrIM1Gag-Pol polyprotein3.4.23.160.473
1qbu846Gag-Pol polyprotein3.4.23.160.473
2qi0MZ3Gag-Pol polyprotein/0.473
3livE16Protease/0.473
4dfg0JVGag-Pol polyprotein3.4.23.160.473
4j5j478Gag-Pol polyprotein3.4.23.160.473
3uhl2NCGag-Pol polyprotein3.4.23.160.472
1msmJE2Gag-Pol polyprotein3.4.23.160.471
3ufnROCGag-Pol polyprotein/0.471
1ajvNMBGag-Pol polyprotein3.4.23.160.470
2q641UNGag-Pol polyprotein3.4.23.160.470
1hpxKNIGag-Pol polyprotein/0.469
1g35AHFGag-Pol polyprotein3.4.23.160.468
3bxrDRRGag-Pol polyprotein3.4.23.160.468
3d20017Gag-Pol polyprotein3.4.23.160.468
3qroNK9Gag-Pol polyprotein3.4.23.160.468
3toh079Gag-Pol polyprotein2.7.7.490.468
2z54AB1Gag-Pol polyprotein3.4.23.160.467
3o9dK19Pol polyprotein/0.467
3o9gF53Gag-Pol polyprotein/0.467
3qpjN4IGag-Pol polyprotein3.4.23.160.467
2b60RITPol polyprotein/0.466
2z4o065Gag-Pol polyprotein3.4.23.160.466
3d1z017Gag-Pol polyprotein3.4.23.160.466
3nuj478Gag-Pol polyprotein3.4.23.160.466
3nwxKVSGag-Pol polyprotein3.4.23.160.466
3sa8K83Protease/0.466
3bheBZNGag-Pol polyprotein3.4.23.160.465
1qbsDMPGag-Pol polyprotein3.4.23.160.464
3i7eDJRGag-Pol polyprotein/0.464
4hla017Gag-Pol polyprotein3.4.23.160.464
1hiiC20Gag-Pol polyprotein/0.463
3aidARQGag-Pol polyprotein3.4.23.160.463
2p3c3TLProtease/0.462
2psuMUUProtease/0.462
1meuDMPGag-Pol polyprotein3.4.23.160.461
2pym1UNGag-Pol polyprotein3.4.23.160.461
2qi4MZ6Gag-Pol polyprotein/0.461
3ekx1UNGag-Pol polyprotein3.4.23.160.461
4i8zG08Gag-Pol polyprotein3.4.23.160.461
1c6x3INProtease/0.460
3cyw017Gag-Pol polyprotein3.4.23.160.460
3nls016Gag-Pol polyprotein3.4.23.160.460
1tcwIM1Gag-Pol polyprotein/0.459
3mws017Pol protein/0.459
3nu6478Gag-Pol polyprotein3.4.23.160.459
1bwaXV6Gag-Pol polyprotein3.4.23.160.458
1k2c0Q4Gag-Pol polyprotein3.4.23.160.458
1mesDMPGag-Pol polyprotein3.4.23.160.458
3oxw017Gag-Pol polyprotein3.4.23.160.458
2bbbHH1Gag-Pol polyprotein3.4.23.160.456
3el01UNGag-Pol polyprotein3.4.23.160.456
3mxdK53Gag-Pol polyprotein3.4.23.160.456
3tof076Gag-Pol polyprotein2.7.7.490.456
1g2kNM1Gag-Pol polyprotein3.4.23.160.455
1sguMK1Gag-Pol polyprotein3.4.23.160.455
2q631UNGag-Pol polyprotein3.4.23.160.455
3o9hK2EGag-Pol polyprotein/0.455
1c70L75Protease/0.454
1ebk0Q4Gag-Pol polyprotein3.4.23.160.454
2r43G3GGag-Pol polyprotein3.4.23.160.454
3lzs017Gag-Pol polyprotein3.4.23.160.454
4dqf017Gag-Pol polyprotein/0.454
4j54G52Gag-Pol polyprotein3.4.23.160.454
3ggu017Gag-Pol polyprotein3.4.23.160.453
3oxv478Gag-Pol polyprotein3.4.23.160.453
2r38G4GGag-Pol polyprotein3.4.23.160.452
3oy4017Gag-Pol polyprotein3.4.23.160.452
1ajxAH1Gag-Pol polyprotein3.4.23.160.451
1hwr216Gag-Pol polyprotein3.4.23.160.451
2bpxMK1Gag-Pol polyprotein3.4.23.160.451
3lzv017Gag-Pol polyprotein3.4.23.160.451
3lzu017Gag-Pol polyprotein3.4.23.160.450
1d4hBEHGag-Pol polyprotein3.4.23.160.449
2psvMUVProtease/0.449
1proA88Gag-Pol polyprotein/0.448
1qbt146Gag-Pol polyprotein3.4.23.160.448
2q55MU0Protease/0.448
2qi1MZ4Gag-Pol polyprotein/0.448
3nu3478Gag-Pol polyprotein3.4.23.160.448
4gb20LQGag-Pol polyprotein2.7.7.490.448
1hbvGANGag-Pol polyprotein/0.447
1odyLP1Gag-Pol polyprotein3.4.23.160.447
3o9aK14Pol polyprotein/0.447
2i0dMUTProtease/0.446
1bwb146Gag-Pol polyprotein3.4.23.160.445
4q1w017Gag-Pol polyprotein3.4.23.160.445
1d4jMSCGag-Pol polyprotein3.4.23.160.443
2r3wG3GGag-Pol polyprotein3.4.23.160.443
3ec0GRLGag-Pol polyprotein3.4.23.470.442
2r3tG4GGag-Pol polyprotein3.4.23.160.441
3lixE17Protease/0.441
3o99K13Pol polyprotein/0.441
3qihFG7Gag-Pol polyprotein3.4.23.160.441
1hpv478Gag-Pol polyprotein/0.440
2hs1017Protease/0.440
3ucb017Gag-Pol polyprotein/0.440