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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.11.000
1x8b824Wee1-like protein kinase2.7.10.20.515
2w5aADPSerine/threonine-protein kinase Nek22.7.11.10.498
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.478
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.473
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.473
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.472
3gwfNAPCyclohexanone monooxygenase/0.464
2qoqANPEphrin type-A receptor 32.7.10.10.462
3cr0809Wee1-like protein kinase2.7.10.20.462
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.462
4qmlANPSerine/threonine-protein kinase 242.7.11.10.458
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
2puiADPMethylthioribose kinase2.7.1.1000.456
2z2w770Wee1-like protein kinase2.7.10.20.456
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.454
4ii5ADPCyclin-dependent kinase 22.7.11.220.453
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
5dnrATPAurora kinase A2.7.11.10.452
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.450
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.448
2in6839Wee1-like protein kinase2.7.10.20.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.446
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.446
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.445
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
1eioGCHGastrotropin/0.443
2henADPEphrin type-B receptor 22.7.10.10.443
3plsANPMacrophage-stimulating protein receptor2.7.10.10.443
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.443
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
1qiqACCIsopenicillin N synthase1.21.3.10.441
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
4ztvTA7Anthranilate phosphoribosyltransferase/0.441
2c6eHPMAurora kinase A2.7.11.10.440
2xvv9DNSerum albumin/0.440
3bi6396Wee1-like protein kinase2.7.10.20.440
3gwfFADCyclohexanone monooxygenase/0.440
4z34ON7Lysophosphatidic acid receptor 1/0.440