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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t41ID5Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1t41ID5Aldose reductase1.1.1.211.000
1t40ID5Aldose reductase1.1.1.210.684
1z8962PAldose reductase1.1.1.210.673
2ikj393Aldose reductase1.1.1.210.672
4gca2X9Aldose reductase1.1.1.210.663
2dv0ZSTAldose reductase1.1.1.210.652
2iki388Aldose reductase1.1.1.210.649
2pdmZSTAldose reductase1.1.1.210.649
3m64393Aldose reductase1.1.1.210.649
3m4h388Aldose reductase1.1.1.210.648
3lqlLDTAldose reductase1.1.1.210.644
2fz9ZSTAldose reductase1.1.1.210.642
3t423T4Aldose reductase1.1.1.210.634
2pdxZSTAldose reductase1.1.1.210.633
2pdp393Aldose reductase1.1.1.210.628
2fz8ZSTAldose reductase1.1.1.210.627
1z3n3NAAldose reductase1.1.1.210.626
3lboLDTAldose reductase1.1.1.210.626
2duxZSTAldose reductase1.1.1.210.621
4yu153NAldose reductase1.1.1.210.619
2hv5ZSTAldose reductase1.1.1.210.618
2pdu393Aldose reductase1.1.1.210.611
3ld5LDTAldose reductase1.1.1.210.611
2ikhLITAldose reductase1.1.1.210.609
2qxwLDTAldose reductase1.1.1.210.609
2pdg47DAldose reductase1.1.1.210.605
2pdbZSTAldose reductase1.1.1.210.601
3lz5LDTAldose reductase1.1.1.210.596
3mb9ZSTAldose reductase1.1.1.210.596
2pdh47DAldose reductase1.1.1.210.595
2pd5ZSTAldose reductase1.1.1.210.593
2pdfZSTAldose reductase1.1.1.210.592
3lenZSTAldose reductase1.1.1.210.592
2i17LDTAldose reductase1.1.1.210.585
2i16LDTAldose reductase1.1.1.210.583
3g5eQ74Aldose reductase1.1.1.210.582
3ghsLDTAldose reductase1.1.1.210.579
3ghuLDTAldose reductase1.1.1.210.579
3ghrLDTAldose reductase1.1.1.210.577
2pdc393Aldose reductase1.1.1.210.576
2pdn47DAldose reductase1.1.1.210.576
2duzZSTAldose reductase1.1.1.210.570
3ghtLDTAldose reductase1.1.1.210.568
2hvoZSTAldose reductase1.1.1.210.557
1pwlBFIAldose reductase1.1.1.210.553
1us0LDTAldose reductase1.1.1.210.550
1ieiZESAldose reductase1.1.1.210.546
3mc5393Aldose reductase1.1.1.210.545
2pzn393Aldose reductase1.1.1.210.543
2fzdTOLAldose reductase1.1.1.210.541
3m0iZSTAldose reductase1.1.1.210.534
2pdlTOLAldose reductase1.1.1.210.533
1ah3TOLAldose reductase1.1.1.210.521
1frbZSTAldose reductase-related protein 2/0.508
2pdq47DAldose reductase1.1.1.210.488
2agtFIDAldose reductase1.1.1.210.479
5liu388Aldo-keto reductase family 1 member B101.1.10.479
2fzbTOLAldose reductase1.1.1.210.477
4dbw511Aldo-keto reductase family 1 member C3/0.477
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
1el3I84Aldose reductase1.1.1.210.460
3f3y4OABile salt sulfotransferase2.8.2.140.459
1ry0PG2Aldo-keto reductase family 1 member C3/0.458
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
4li61XOTankyrase-12.4.2.300.455
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2xupTZ5Acetylcholinesterase3.1.1.70.452
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.452
4hyf1AKTankyrase-22.4.2.300.451
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.450
1gjrFADFerredoxin--NADP reductase1.18.1.20.450
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2pdwFIDAldose reductase1.1.1.210.450
1ry8RUTAldo-keto reductase family 1 member C3/0.449
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.449
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2aotSAHHistamine N-methyltransferase2.1.1.80.449
2cekN8TAcetylcholinesterase3.1.1.70.449
1tfz8694-hydroxyphenylpyruvate dioxygenase1.13.11.270.448
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.448
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.448
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.448
4u163C0Muscarinic acetylcholine receptor M3/0.448
2xuhTZ4Acetylcholinesterase3.1.1.70.446
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2inzOHPAldose reductase1.1.1.210.445
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.445
3p2vDOYAldose reductase1.1.1.210.445
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.445
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.445
1gt5BZQOdorant-binding protein/0.444
2rd2QSIGlutamine--tRNA ligase6.1.1.180.444
3af1GDPPantothenate kinase2.7.1.330.444
3jq8DX3Pteridine reductase, putative/0.444
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.444
2vqqTFGHistone deacetylase 43.5.1.980.443
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
1x8lOXRRetinol dehydratase/0.442
2qryTPSThiamine-binding periplasmic protein/0.442
3ghvGHCDihydrofolate reductase1.5.1.30.442
3ug8IMNAldo-keto reductase family 1 member C3/0.442
4phlPILPhosphodiesterase/0.442
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.440
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.440
2oazI96Methionine aminopeptidase 2/0.440
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.440