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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1svgI04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.673
1xh6R94cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.618
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.606
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
1xh9R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.586
1svhI08cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.584
1xh8R55cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.584
1xh4R69cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.576
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.514
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.505
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.499
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2vnwM01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.491
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446