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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rw8580TGF-beta receptor type-12.7.11.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1rw8580TGF-beta receptor type-12.7.11.301.000
2wotZZGTGF-beta receptor type-12.7.11.300.588
1vjy460TGF-beta receptor type-12.7.11.300.574
3gxlQIGTGF-beta receptor type-12.7.11.300.552
5e8wSTUTGF-beta receptor type-12.7.11.300.546
4c02TAKActivin receptor type-12.7.11.300.543
1py5PY1TGF-beta receptor type-12.7.11.300.540
3hmm855TGF-beta receptor type-12.7.11.300.535
3mtfA3FActivin receptor type-12.7.11.300.534
4dymIYZActivin receptor type-12.7.11.300.530
5e92ANPTGF-beta receptor type-22.7.11.300.522
1u4dDBQActivated CDC42 kinase 1/0.517
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.495
3oom507Activin receptor type-12.7.11.300.492
4riyADPEpidermal growth factor receptor2.7.10.10.486
1u54ACPActivated CDC42 kinase 1/0.485
4bgg844Activin receptor type-12.7.11.300.477
2qo9ANPEphrin type-A receptor 32.7.10.10.475
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.474
4lopSB4Mitogen-activated protein kinase 14/0.473
3a60STURibosomal protein S6 kinase beta-12.7.11.10.472
4i22IREEpidermal growth factor receptor2.7.10.10.472
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.470
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.470
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.468
2xikJ60Serine/threonine-protein kinase 252.7.11.10.468
3gubGUBDeath-associated protein kinase 12.7.11.10.464
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.464
4fks46KCyclin-dependent kinase 22.7.11.220.463
4qmpDKISerine/threonine-protein kinase 242.7.11.10.462
5e8xSTUTGF-beta receptor type-12.7.11.300.462
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.461
2cgpCMPcAMP-activated global transcriptional regulator CRP/0.461
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.461
4zseANPEpidermal growth factor receptor2.7.10.10.461
4loqSB4Mitogen-activated protein kinase 14/0.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.458
3w32W32Epidermal growth factor receptor2.7.10.10.458
4y95746Tyrosine-protein kinase/0.457
1gih1PUCyclin-dependent kinase 22.7.11.220.456
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.456
2znq401Peroxisome proliferator-activated receptor delta/0.456
3ggfGVDSerine/threonine-protein kinase 26/0.456
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.456
4gmy0X5Tyrosine-protein kinase JAK2/0.456
2znnS44Peroxisome proliferator-activated receptor alpha/0.455
3hazFADBifunctional protein PutA/0.455
3vryB43Tyrosine-protein kinase HCK2.7.10.20.455
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.455
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.455
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.454
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.454
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.453
2znpK55Peroxisome proliferator-activated receptor delta/0.453
3zh8C58Protein kinase C iota type2.7.11.130.453
4y8wSTRSteroid 21-hydroxylase/0.453
1y0s331Peroxisome proliferator-activated receptor delta/0.452
2nnkROCProtease/0.452
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.452
4jq8KJ8Epidermal growth factor receptor2.7.10.10.451
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
2q5g1FAPeroxisome proliferator-activated receptor delta/0.450
3gi6D78Gag-Pol polyprotein/0.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
4y93746Tyrosine-protein kinase/0.450
1jld0PPGag-Pol polyprotein/0.449
1knuYPAPeroxisome proliferator-activated receptor gamma/0.449
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
3t2zFADSulfide-quinone reductase/0.449
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.449
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.449
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.449
3adaNADSubunit alpha of sarocosine oxidase/0.448
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.448
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.448
3t113T1Gag-Pol polyprotein3.4.23.160.448
4j54G52Gag-Pol polyprotein3.4.23.160.448
4xldBRLPeroxisome proliferator-activated receptor gamma/0.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1yb5NAPQuinone oxidoreductase1.6.5.50.447
1zeoC01Peroxisome proliferator-activated receptor gamma/0.447
2b7zMK1Gag-Pol polyprotein/0.447
2hcdBIVVitamin D3 receptor A/0.447
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.447
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.447
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.447
3vt8YI3Vitamin D3 receptor/0.447
4du82P0Mevalonate diphosphate decarboxylase/0.447
4gg70J8Hepatocyte growth factor receptor2.7.10.10.447
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1t7j478Gag-Pol polyprotein3.4.23.160.446
3bxsDRSGag-Pol polyprotein3.4.23.160.446
3em6017Gag-Pol polyprotein3.4.23.160.446
3sp9IL2Peroxisome proliferator-activated receptor delta/0.446
3lixE17Protease/0.445
3pwrROCGag-Pol polyprotein3.4.23.160.445
3sa8K83Protease/0.445
3sabF78Protease/0.445
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4kl9NDPDihydrofolate reductase1.5.1.30.445
1rl8RITGag-Pol polyprotein3.4.23.160.444
2eufLQQCyclin-dependent kinase 62.7.11.220.444
2qboCAMCamphor 5-monooxygenase1.14.15.10.444
3a9wNADNDP-sugar epimerase/0.444
3zptM8YGag-Pol polyprotein3.4.23.160.444
4h3qANPMitogen-activated protein kinase 12.7.11.240.444
4hjoAQ4Epidermal growth factor receptor2.7.10.10.444
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4yuqKS1Calmodulin-like domain protein kinase/0.444
2bpy3INGag-Pol polyprotein3.4.23.160.443
2j5xGSPADP-ribosylation factor 6/0.443
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
3jvy017Gag-Pol polyprotein3.4.23.160.443
3l8p0CEAngiopoietin-1 receptor2.7.10.10.443
3pqbVGPPutative oxidoreductase/0.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.443
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.443
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1ivp1ZKGag-Pol polyprotein/0.442
2c6tDT5Cyclin-dependent kinase 22.7.11.220.442
2vv9IM9Cyclin-dependent kinase 22.7.11.220.442
3sa4F72Protease/0.442
4j55031Gag-Pol polyprotein3.4.23.160.442
4ye3G04Gag-Pol polyprotein3.4.23.160.442
2dwbANPAurora kinase A2.7.11.10.441
2qblCAMCamphor 5-monooxygenase1.14.15.10.441
2uzeC95Cyclin-dependent kinase 22.7.11.220.441
2y9qANPMitogen-activated protein kinase 12.7.11.240.441
4kb81QOCasein kinase I isoform delta2.7.11.10.441
4nxvGDPMitochondrial dynamics protein MID51/0.441
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.440
1sduMK1Gag-Pol polyprotein3.4.23.160.440
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2gtk208Peroxisome proliferator-activated receptor gamma/0.440
2q9fC3SCholesterol 24-hydroxylase/0.440
2qi3MZ5Gag-Pol polyprotein/0.440
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
3rk708ZCyclin-dependent kinase 22.7.11.220.440
3w33W19Epidermal growth factor receptor2.7.10.10.440
4nxuADPMitochondrial dynamics protein MID51/0.440