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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1rbqKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.21.000
1rbmKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.622
1rbyGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.605
1njsKEUTrifunctional purine biosynthetic protein adenosine-32.1.2.20.593
1rc0KT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.584
1c2tNHSPhosphoribosylglycinamide formyltransferase/0.558
1c2tGARPhosphoribosylglycinamide formyltransferase/0.557
1c3eGARPhosphoribosylglycinamide formyltransferase/0.549
1c3eNHRPhosphoribosylglycinamide formyltransferase/0.536
1menGARTrifunctional purine biosynthetic protein adenosine-32.1.2.20.535
1rbzKT5Trifunctional purine biosynthetic protein adenosine-32.1.2.20.524
1cdeGARPhosphoribosylglycinamide formyltransferase/0.508
1cdeDZFPhosphoribosylglycinamide formyltransferase/0.505
1jkx138Phosphoribosylglycinamide formyltransferase/0.451
3tz3B36Acetyl-CoA carboxylase/0.440