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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pmv537Mitogen-activated protein kinase 102.7.11.24

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pmv537Mitogen-activated protein kinase 102.7.11.241.000
2p33J07Mitogen-activated protein kinase 102.7.11.240.587
3cgfJNFMitogen-activated protein kinase 102.7.11.240.549
1pmn984Mitogen-activated protein kinase 102.7.11.240.546
3cgoJNOMitogen-activated protein kinase 102.7.11.240.535
2o2u738Mitogen-activated protein kinase 102.7.11.240.528
3ttiKBIMitogen-activated protein kinase 102.7.11.240.514
2xrwANPMitogen-activated protein kinase 82.7.11.240.507
3ttjJBIMitogen-activated protein kinase 102.7.11.240.502
3kvxFMYMitogen-activated protein kinase 102.7.11.240.488
3eljGS7Mitogen-activated protein kinase 82.7.11.240.487
4jbpYPHAurora kinase A2.7.11.10.483
2b1pAIZMitogen-activated protein kinase 102.7.11.240.469
4jboWPHAurora kinase A2.7.11.10.468
3oroAGSSerine/threonine protein kinase/0.463
4y93746Tyrosine-protein kinase/0.463
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
1i44ACPInsulin receptor2.7.10.10.460
1jnkANPMitogen-activated protein kinase 102.7.11.240.459
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.459
3oriAGSSerine/threonine protein kinase/0.458
3ormAGSSerine/threonine protein kinase/0.457
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.457
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
4o0uADNAurora kinase A2.7.11.10.455
4y95746Tyrosine-protein kinase/0.455
2h96893Mitogen-activated protein kinase 82.7.11.240.454
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.453
4ux9ANPMitogen-activated protein kinase 82.7.11.240.453
4jia1K3Tyrosine-protein kinase JAK2/0.452
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.452
1rj6AZMCarbonic anhydrase 144.2.1.10.450
5e8ySTUTGF-beta receptor type-22.7.11.300.449
2gjnFMNNitronate monooxygenase1.13.12.160.448
2j4z626Aurora kinase A2.7.11.10.448
2b53D23Cyclin-dependent kinase 22.7.11.220.446
3k5uPFQAurora kinase A2.7.11.10.444
4btjADPTau-tubulin kinase 12.7.11.10.440