sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1njf | AGS | DNA polymerase III subunit tau | 2.7.7.7 | 1.000 | |
| 2voj | NAD | Alanine dehydrogenase | 1.4.1.1 | 0.492 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.470 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.465 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.465 | |
| 2q0l | FAD | Thioredoxin reductase | 1.8.1.9 | 0.462 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.456 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.454 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.453 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 5ftf | ADP | TPR domain protein | / | 0.452 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.451 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.451 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.449 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.449 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.448 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.447 | |
| 2pmd | GNP | Translation initiation factor 2 subunit gamma | / | 0.447 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.447 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.447 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.446 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.446 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.445 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.445 | |
| 1w49 | APC | NTPase P4 | / | 0.444 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 1w48 | APC | NTPase P4 | / | 0.443 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.443 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.442 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.442 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.442 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3cgo | JNO | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.440 |