sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1m2o | GNP | Small COPII coat GTPase SAR1 | 3.6.5 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1m2o | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 1.000 | |
| 3r9x | GNP | GTPase Era | / | 0.491 | |
| 3cx6 | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.488 | |
| 5di3 | GNP | ADP-ribosylation factor-like protein 3 | / | 0.486 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.482 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.482 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.478 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.478 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.472 | |
| 2q3f | GNP | Ras-related GTP-binding protein D | / | 0.472 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.471 | |
| 4fvq | ATP | Tyrosine-protein kinase JAK2 | / | 0.470 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.469 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.468 | |
| 2oo7 | AP5 | Adenylate kinase | / | 0.468 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.467 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.467 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.467 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.465 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.465 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.464 | |
| 2qtv | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.463 | |
| 3b1x | GNP | Ferrous iron transport protein B | / | 0.463 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.461 | |
| 1svm | ATP | Large T antigen | 3.6.4 | 0.458 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.458 | |
| 3jvv | ACP | Twitching mobility protein | / | 0.458 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.456 | |
| 1bof | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.454 | |
| 1njf | ADP | DNA polymerase III subunit tau | 2.7.7.7 | 0.454 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.454 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.453 | |
| 1dvr | ATF | Adenylate kinase | / | 0.451 | |
| 3r7w | GNP | GTP-binding protein GTR2 | / | 0.451 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.451 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.451 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.450 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.450 | |
| 1sxj | AGS | Replication factor C subunit 1 | / | 0.448 | |
| 1e4y | AP5 | Adenylate kinase | / | 0.446 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.446 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.446 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.445 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.445 | |
| 1rj9 | GCP | Signal recognition particle receptor FtsY | / | 0.444 | |
| 1ky2 | GNP | GTP-binding protein YPT7 | / | 0.443 | |
| 1okk | GCP | Signal recognition particle protein | / | 0.443 | |
| 1okk | GCP | Signal recognition particle receptor FtsY | / | 0.443 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.443 | |
| 4xvu | ATP | ATPase GET3 | / | 0.443 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.442 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2cls | GTP | Rho-related GTP-binding protein Rho6 | / | 0.441 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.441 | |
| 4v02 | ATP | Site-determining protein | / | 0.441 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.440 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 4lj9 | ACP | Chaperone protein ClpB | / | 0.440 | |
| 4qbg | AP5 | Adenylate kinase | / | 0.440 |