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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lpfFADDihydrolipoyl dehydrogenase1.8.1.4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1lpfFADDihydrolipoyl dehydrogenase1.8.1.41.000
3ladFADDihydrolipoyl dehydrogenase/0.609
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.573
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.553
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.549
2eq9FADDihydrolipoyl dehydrogenase/0.533
4jq9FADDihydrolipoyl dehydrogenase/0.528
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.526
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.521
2yquFADDihydrolipoyl dehydrogenase/0.516
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.511
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.509
3urhFADDihydrolipoyl dehydrogenase/0.497
1zk7FADMercuric reductase1.16.1.10.494
1zx9FADMercuric reductase1.16.1.10.488
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.485
3cgbFADCoenzyme A disulfide reductase/0.454
2r9zFADGlutathione amide reductase/0.448
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.444
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.443
1xdiFADNAD(P)H dehydrogenase (quinone)/0.440
3cgcFADCoenzyme A disulfide reductase/0.440