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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jutLYDThymidylate synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1jutLYDThymidylate synthase/1.000
2tscCB3Thymidylate synthase/0.565
1aiqCB3Thymidylate synthase/0.557
1kceCB3Thymidylate synthase/0.556
1fwmCB3Thymidylate synthase/0.526
1tsdF89Thymidylate synthase/0.520
1f4fTP3Thymidylate synthase/0.517
2bbqPFGThymidylate synthase/0.512
1dnaCB3Thymidylate synthase/0.509
1zprCB3Thymidylate synthase/0.504
1kziTHGThymidylate synthase/0.502
1jtqLY3Thymidylate synthase/0.501
1tduCB3Thymidylate synthase/0.500
2kceD16Thymidylate synthase/0.500
1kzjCB3Thymidylate synthase/0.494
3bhlTHGThymidylate synthase/0.491
1ju6LYAThymidylate synthase2.1.1.450.481
1nceCB3Thymidylate synthase/0.479
1hvyD16Thymidylate synthase2.1.1.450.478
2ftoCB3Thymidylate synthase/0.478
4fogC2FThymidylate synthase ThyA/0.476
1f4gTP4Thymidylate synthase/0.475
1jtuLYBThymidylate synthase/0.473
3bgxMEFThymidylate synthase/0.473
1tysDHFThymidylate synthase/0.469
1trgCB3Thymidylate synthase/0.460
1tduDURThymidylate synthase/0.459
1jujLYAThymidylate synthase2.1.1.450.456
4gevCB3Thymidylate synthase/0.456
4ez8DHFThymidylate synthase2.1.1.450.455
1an5CB3Thymidylate synthase/0.454
1dduCB3Thymidylate synthase/0.453
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.441
4knzCB3Thymidylate synthase/0.441