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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1isjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.6

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1isjNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.61.000
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.543
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.492
4arbC57Acetylcholinesterase3.1.1.70.467
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.465
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
1e6zNGOChitinase/0.459
2v57PRLTetR family transcriptional regulator/0.457
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
2bjsACVIsopenicillin N synthase1.21.3.10.455
2j7cIDEBeta-glucosidase A3.2.1.210.455
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.455
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.455
3p5sAVUCD38 molecule/0.455
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.455
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.454
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.453
2j7dGI1Beta-glucosidase A3.2.1.210.452
3h0wN8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.451
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2pb1NFGGlucan 1,3-beta-glucosidase/0.450
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.449
3ugrIMNAldo-keto reductase family 1 member C3/0.449
2ycxP32Beta-1 adrenergic receptor/0.449
2pdh47DAldose reductase1.1.1.210.448
3dz6M8ES-adenosylmethionine decarboxylase proenzyme4.1.1.500.448
4bjcRPBTankyrase-22.4.2.300.448
5cc9DDFDihydrofolate reductase1.5.1.30.448
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1srfMTBStreptavidin/0.447
2f3815MAldo-keto reductase family 1 member C3/0.447
4au7SAHHistone-lysine N-methyltransferase KMT5C2.1.1.430.447
4dbw511Aldo-keto reductase family 1 member C3/0.447
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
3htjETEbrA repressor/0.446
4jvlESTEstrogen sulfotransferase2.8.2.40.446
2cdcNAPGlucose 1-dehydrogenase/0.445
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3hthPRLEbrA repressor/0.444
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.444
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.443
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3rm8RM8Acidic mammalian chitinase3.2.1.140.443
2d06ESTSulfotransferase 1A12.8.2.10.442
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.442
2pdfZSTAldose reductase1.1.1.210.441
1u08PLPMethionine aminotransferase/0.440
1xf0ASDAldo-keto reductase family 1 member C3/0.440
2b82ADNClass B acid phosphatase3.1.3.20.440
2cdaNAPGlucose 1-dehydrogenase/0.440
2hzqSTRApolipoprotein D/0.440
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.440