Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1fvv107Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1fvv107Cyclin-dependent kinase 22.7.11.221.000
2w17I19Cyclin-dependent kinase 22.7.11.220.539
3rak03ZCyclin-dependent kinase 22.7.11.220.532
2vv9IM9Cyclin-dependent kinase 22.7.11.220.519
3qxpX64Cyclin-dependent kinase 22.7.11.220.513
3nux3NVCyclin-dependent kinase 62.7.11.220.508
2uzbC75Cyclin-dependent kinase 22.7.11.220.507
2uzdC85Cyclin-dependent kinase 22.7.11.220.503
2w05FRTCyclin-dependent kinase 22.7.11.220.498
3s1h56ZCyclin-dependent kinase 22.7.11.220.490
4bcmT7ZCyclin-dependent kinase 22.7.11.220.486
3nynSGVG protein-coupled receptor kinase 62.7.11.160.480
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.479
4eooATPCyclin-dependent kinase 22.7.11.220.476
2j9mPY8Cyclin-dependent kinase 22.7.11.220.474
2vu3LZECyclin-dependent kinase 22.7.11.220.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.473
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.470
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.469
2fvdLIACyclin-dependent kinase 22.7.11.220.468
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.466
3my5RFZCyclin-dependent kinase 22.7.11.220.465
3ezvEZVCyclin-dependent kinase 22.7.11.220.464
3gu7ADPDeath-associated protein kinase 12.7.11.10.461
3rkb12ZCyclin-dependent kinase 22.7.11.220.461
4fx360KCyclin-dependent kinase 22.7.11.220.460
1finATPCyclin-dependent kinase 22.7.11.220.459
3at4CCKCasein kinase II subunit alpha2.7.11.10.456
4fkv61KCyclin-dependent kinase 22.7.11.220.456
1p2a5BNCyclin-dependent kinase 22.7.11.220.455
2vttLZDCyclin-dependent kinase 22.7.11.220.455
4e6d0NUTyrosine-protein kinase JAK2/0.455
2btsU32Cyclin-dependent kinase 22.7.11.220.454
3be9P04Casein kinase II subunit alpha2.7.11.10.454
2ckeIQUDeath-associated protein kinase 2/0.453
4f081RSTyrosine-protein kinase JAK2/0.452
4ez50RSCyclin-dependent kinase 62.7.11.220.451
1qmzATPCyclin-dependent kinase 22.7.11.220.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.450
4j95ACPFibroblast growth factor receptor 2/0.450
1pxmCK5Cyclin-dependent kinase 22.7.11.220.449
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.449
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.449
3pe2E1BCasein kinase II subunit alpha2.7.11.10.448
5dt0SKEAurora kinase A2.7.11.10.448
2c6iDT1Cyclin-dependent kinase 22.7.11.220.446
3i60E86Mitogen-activated protein kinase 12.7.11.240.446
4aqc88ATyrosine-protein kinase JAK2/0.446
1gii1PUCyclin-dependent kinase 22.7.11.220.445
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.445
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.443
4grb0XGCasein kinase II subunit alpha2.7.11.10.443
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.442
1jstATPCyclin-dependent kinase 22.7.11.220.440
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.440
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.440