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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1febFADTrypanothione reductase1.8.1.12

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1febFADTrypanothione reductase1.8.1.121.000
1bzlFADTrypanothione reductase1.8.1.120.546
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.527
1gerFADGlutathione reductase1.8.1.70.526
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.524
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.521
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.518
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.512
1grhFADGlutathione reductase, mitochondrial1.8.1.70.510
3grsFADGlutathione reductase, mitochondrial1.8.1.70.510
4nevFADTrypanothione reductase/0.507
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.487
4j56FADThioredoxin reductase 21.8.1.90.484
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.465
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.463
1grgFADGlutathione reductase, mitochondrial1.8.1.70.463
1feaFADTrypanothione reductase1.8.1.120.462
1greFADGlutathione reductase, mitochondrial1.8.1.70.462
4jq9FADDihydrolipoyl dehydrogenase/0.460
2hqmFADGlutathione reductase1.8.1.70.458
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.451
1zk7FADMercuric reductase1.16.1.10.447
2jk6FADTrypanothione reductase/0.445
1fecFADTrypanothione reductase1.8.1.120.443