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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1adsNAPAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1adsNAPAldose reductase1.1.1.211.000
1z8aNAPAldose reductase1.1.1.210.704
2iq0NAPAldose reductase1.1.1.210.658
2acuNAPAldose reductase1.1.1.210.651
2acqNAPAldose reductase1.1.1.210.646
2j8tNAPAldose reductase1.1.1.210.642
1x98NAPAldose reductase1.1.1.210.633
2acsNAPAldose reductase1.1.1.210.630
1ah4NAPAldose reductase1.1.1.210.626
3q65NAPAldose reductase1.1.1.210.616
1x96NAPAldose reductase1.1.1.210.614
3v36NAPAldose reductase1.1.1.210.614
2pf8NDPAldose reductase1.1.1.210.608
3q67NAPAldose reductase1.1.1.210.605
1az2NAPAldose reductase1.1.1.210.602
2pfhNDPAldose reductase1.1.1.210.579
2pevNDPAldose reductase1.1.1.210.577
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.536
3qkzNAPAldose reductase-related protein 11.1.1.210.531
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.525
3o3rNAPAldose reductase-related protein 11.1.1.210.516
4g5dNDPProstaglandin F synthase1.1.1.1880.500
1c9wNAPAldose reductase-related protein 2/0.498
3h7rNAPAldo-keto reductase family 4 member C8/0.487
2hdjNDPAldo-keto reductase family 1 member C2/0.478
4xo7NAPAldo-keto reductase family 1 member C2/0.475
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.473
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.468
2hejNDPAldo-keto reductase family 1 member C211.1.10.461
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.457
4l1xNAPAldo-keto reductase family 1 member C2/0.457
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.450
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.448
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.445
1s1rNAPAldo-keto reductase family 1 member C3/0.444
1zgdNAPChalcone reductase/0.442