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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5fsyAR6Uncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5fsyAR6Uncharacterized protein/1.000
5fsxADPUncharacterized protein/0.580
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.544
5cb3APRO-acetyl-ADP-ribose deacetylase/0.527
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.504
5cb5APRO-acetyl-ADP-ribose deacetylase/0.498
2favAPRNonstructural polyprotein pp1a/0.485
3ewrAPRReplicase polyprotein 1a3.4.220.484
5cmsAPRO-acetyl-ADP-ribose deacetylase/0.484
3sigAR6Uncharacterized protein/0.483
1dliUDXUDP-glucose 6-dehydrogenase/0.472
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.472
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.470
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.469
4i4b1CV3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.469
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.467
3gqoAPRNon-structural polyprotein/0.465
1ty8ADPProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.464
1txzAPRProbable ADP-ribose 1''-phosphate phosphatase YML087W3.1.3.840.463
1xe55FEPlasmepsin-23.4.23.390.459
2gjlFMNNitronate monooxygenase1.13.12.160.458
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.457
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.457
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.457
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.456
4xq9NADHomospermidine synthase2.5.1.440.455
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.454
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.453
3fp0FP015-O-acetyltransferase/0.452
4tvbNADHomospermidine synthase2.5.1.440.451
5hwpCOAHydroxymethylglutaryl-CoA synthase/0.451
2givACOHistone acetyltransferase KAT8/0.450
3phiNDPShikimate dehydrogenase (NADP(+))/0.450
3qt62P0Mevalonate diphosphate decarboxylase/0.450
4ambDUDPutative glycosyl transferase/0.449
1ep1FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit1.3.1.140.448
2fa3ACOHydroxymethylglutaryl-CoA synthase/0.448
4b1jA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.448
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.448
4m83ERYOleandomycin glycosyltransferase2.4.10.448
4xqcNADHomospermidine synthase2.5.1.440.448
1dr2TAPDihydrofolate reductase1.5.1.30.447
4ji91M3Tyrosine-protein kinase JAK2/0.446
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.445
4na4A1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.445
4oztP1AEcdysone receptor, putative/0.445
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.444
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.444
3f63GTXGlutathione transferase GST1-4/0.444
3w8dNAD3-hydroxybutyrate dehydrogenase/0.444
3a6qFMNFMN-binding protein/0.442
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
1cg3IMOAdenylosuccinate synthetase/0.440
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.440
4oznATPAmmonium transporter/0.440